ArticleBMJ open2023
Association between BUN/creatinine ratio and the risk of in-hospital mortality in patients with trauma-related acute respiratory distress syndrome: a single-centre retrospective cohort from the MIMIC database.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Association between blood urea nitrogen trajectory phenotypes and prognosis in patients with sepsis: a multicenter retrospective cohort study.BMC infectious diseases · 2026Observational
- Renal function dynamics in COVID-19: exploring biomarker interactions with D-dimer and C-reactive proteins.Bioscience reports · 2026Article
- Association between blood urea nitrogen-to-creatinine ratio and mortality risk in critically ill patients with ventilator-associated pneumonia: a retrospective study.Frontiers in medicine · 2026Article
- Risk Prediction of Acute Kidney Injury in Patients with HBV-Related Acute-on-Chronic Liver Failure.International journal of general medicine · 2026Article
- Analysis of pathogen spectrum changes and epidemiological characteristics of superficial mycosis in the Shantou region of China from 2022 to 2024.American journal of translational research · 2026Article
- Predictive performance of blood urea nitrogen, cystatin C, and their ratio for in-hospital mortality in sepsis: a Chinese two-center analysis.Open medicine (Warsaw, Poland) · 2026Article
- The correlation between blood urea nitrogen to creatinine ratio and short-term and long-term all-cause mortality in sepsis-associated acute kidney injury patients aged 50 and above: a large retrospective cohort study.Frontiers in endocrinology · 2026Article
- Association between blood urea nitrogen-to-creatinine ratio and 28-day mortality in acute kidney injury patients undergoing continuous renal replacement therapy.Scientific reports · 2025Article
- Association Between the Blood Urea Nitrogen-to-Creatinine Ratio Trajectories and Clinical Outcomes in Critically Ill Hemorrhagic Stroke Patients: Insights from MIMIC-IV Database.Journal of clinical medicine · 2025Article
- Development and validation of a predictive model for hospital mortality in patients with community-acquired pneumonia admitted to the intensive care unit.The Journal of international medical research · 2025Article
- Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study.Scientific reports · 2025Article
- Relationship between blood urea nitrogen and 28-day all-cause mortality in patients with acute pulmonary edema: a retrospective analysis of the MIMIC-IV database.Frontiers in cardiovascular medicine · 2025Article
- Clinical implications of persistently increased blood urea nitrogen/serum creatinine ratio (PI-BUN/Cr) in severe COVID-19 patients.Pneumonia (Nathan Qld.) · 2024Article
- Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain.Journal of neuroinflammation · 2024Article
- The Relationship Between Blood Urea Nitrogen to Creatinine Ratio and Severe Acute Exacerbation of COPD Patients: A Propensity Score Matching Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Blood urea nitrogen to creatinine ratio is associated with in-hospital mortality in critically ill patients with venous thromboembolism: a retrospective cohort study.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent studies have shown that blood urea nitrogen to creatinine (BUN/Cr) ratio might be an effective marker for the prognosis of patients with respiratory diseases. Herein, we aimed to assess the association between BUN/Cr ratio and the risk of in-hospital mortality in patients with trauma-related acute respiratory distress syndrome (ARDS).
designA retrospective cohort study. SETTING AND
participants1034 patients were extracted from the Medical Information Mart for Intensive Care-III (MIMIC-III) database. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome of the study was in-hospital mortality, defined by the vital status at the time of hospital discharge (ie, survivors and non-survivors).
resultsOf the total patients, 191 (18.5%) died in hospital. The median follow-up duration was 16.0 (8.3-26.6) days. The results showed that high level of BUN/Cr ratio was significantly associated with an increased risk of in-hospital mortality (15.54-21.43: HR=2.00, 95% CI: (1.18 to 3.38); >21.43: HR=1.76, 95% CI: (1.04 to 2.99)) of patients with trauma-related ARDS. In patients with trauma-related ARDS that aged ≥65 years old, male and female, Onychomycosis Severity Index (OSI)>98, Revised Trauma Score (RTS)>11, Simplified Acute Physiology Score II (SAPS-II)>37 and sequential organ failure assessment (SOFA) scores≤7, BUN/Cr ratio was also related to the increased risk of in-hospital mortality (all p<0.05). The predictive performance of BUN/Cr ratio for in-hospital mortality was superior to BUN or Cr, respectively, with the area under the curve of receiver operator characteristic curve at 0.6, and that association was observed in age, gender, OSI, RTS, SAPS-II and SOFA score subgroups.
conclusionBUN/Cr ratio may be a potential biomarker for the risk of in-hospital mortality of trauma-related ARDS, which may help the clinicians to identify high-risk individuals and to implement clinical interventions.
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