Evidence map›Paper›PMID 37116583›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023

Transplanting hepatitis B surface antigen-positive livers in the United States: Outcomes and opportunities.

Anshul Bhatnagar, Sameer Prakash, Peter Lymberopoulos, Cameron Goff, Anjiya Shaikh, Donghee Kim, Aijaz Ahmed, Carl Berg, Susanna Naggie, Fasiha Kanwal and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Anshul BhatnagarSchool of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Sameer PrakashMemorial Hermann Hospital The Woodlands, Spring, Texas, USA.
Peter LymberopoulosDepartment of Medicine, State University of New York (SUNY) Downstate, Health Sciences University, Brooklyn, New York, USA.
Cameron GoffSchool of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Anjiya ShaikhDepartment of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Donghee KimDepartment of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA.
Aijaz AhmedDepartment of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA.
Carl BergDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Susanna NaggieDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Fasiha KanwalSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA; Michael E DeBakey VA Medical Center, Houston, TX, USA.
George CholankerilSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA; Division of Abdominal Transplantation, Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Tzu-Hao LeeSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA; Division of Abdominal Transplantation, Department of Surgery, Baylor College of Medicine, Houston, Texas, USA. Electronic address: tzu-hao.Lee@bcm.edu.
Baylor College of Medicine · USDuke University · USStanford University · USMemorial Hermann The Woodlands Hospital · USMichael E. DeBakey VA Medical Center · USState University of New York · USUniversity of Connecticut · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Prevention of Hepatocellular Carcinoma Related to Metabolic SyndromeP01CA263025 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2022 to 2026
$8.9M
Risk Stratification for and Early Detection of Liver CancerU01CA230997 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Jagpreet Chhatwal, Hashem B El-Serag · 2018 to 2026
$6.4M
Clinical Validation Center for Hepatocellular CarcinomaU01CA271887 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FASIHA KANWAL, JORGE A MARRERO · 2022 to 2026
$4.7M
Genome-Wide Association Study (GWAS) in Hepatocellular Carcinoma (HCC)R01CA186566 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., HASSAN, MANAL METWALLY · 2015 to 2019
$3.6M
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease OutcomesR01CA256977 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KANWAL, FASIHA, SINGAL, AMIT · 2021 to 2025
$3.0M
NCI NIH HHS P01 CA263025NCI NIH HHS R01 CA186566NCI NIH HHS R01 CA256977NCI NIH HHS U01 CA230997NCI NIH HHS U01 CA271887NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Livers from donors with positive hepatitis B surface antigens (HBsAg+) have been used to expand the donor pool; however, outcome data are limited. We aim to evaluate survival following liver transplant (LT) from HBsAg+ donors. Using the United Network for Organ Sharing registry, we identified HBsAg+ donors used for LT from 2009 to 2020. We used Kaplan-Meier survival and Cox proportional hazards regression to compare post-LT survival in hepatitis B virus-negative recipients who utilized HBsAg+ donors to propensity-matched cohorts who utilized other types of donors. From 2009-2020, 70 patients received HBsAg+ livers, and 58 of them did not carry a diagnosis of chronic hepatitis B virus. The 1- and 3-year post-LT survival for hepatitis B virus-negative patients who received livers from HBsAg+ donors were 96.6% and 91.4%, respectively, with no statistical differences compared with patients who received livers from hepatitis C virus viremic donors (96.5%/93.0%, P = .961/.427), donation after cardiac death donors (93.0%/86.0%, P = .651/.598), average-risk donors (89.5%/86.0%, P = 0.264/0.617), and a combination of extended-criteria donors, including donation after cardiac death, donor age over 70, and graft with greater than 30% steatosis (93.0%/91.2%, P = .621/.785). Recipients of HBsAg+ livers have similar post-LT survival compared with those receiving other types of grafts. Increasing the utilization of HBsAg+ livers could safely expand the donor pool.

Indexed as

Hepatitis BHepatitis B, ChronicLiver TransplantationGraft SurvivalHepatitis B Surface AntigensHepatitis B virusHumansTissue DonorsUnited StatesHepatitis B Surface Antigensextended-criteria donorshepatitis B virusliver transplantationorgan utilizationposttransplant survival

Identifiers

PMID37116583
PMCPMC13435560
OpenAlexW4367057045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.