Evidence map›Paper›PMID 37116466›Full record

ArticleCell2023

CAND1 orchestrates CRLs through rock and roll.

Yuan Xie, Minglei Zhao

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Reciprocal Regulation Between the SCFbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Yuan XieDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Minglei ZhaoDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. Electronic address: mlzhao@uchicago.edu.

Funding

Mechanosensitive M7G epitranscriptome in endothelial health and diseaseR01HL155909 · NHLBI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2022 to 2025
$2.8M
Structural and Functional Studies of Molecular Machines Involved in Chemical Modifications of MacromoleculesR35GM143052 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHAO, MINGLEI · 2021 to 2025
$2.1M
NHLBI NIH HHS R01 HL155909NIGMS NIH HHS R35 GM143052
6 · The paper itself

Abstract

Proper regulation of protein degradation is essential for cell physiology. In the current issue of Cell, Baek et al. elucidated how a large class of ubiquitin ligase, known as CRL, is assembled and disassembled through a key regulator, CAND1.

Indexed as

Transcription FactorsUbiquitin-Protein LigasesCullin ProteinsProteolysisUbiquitinCAND1 protein, humanCullin ProteinsTranscription FactorsUbiquitinUbiquitin-Protein Ligases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.