ArticleAging2023
Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants.
Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Rethinking immune studies: population-level immune variations and the path forward.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Pooled it
- CD31Physiological reports · 2026Article
- Immune aging biomarkers for clinical trials.Nature medicine · 2026Review
- Article
- Immune cell subsets linking insomnia trajectories and incident cognitive impairment: a prospective cohort study.BMC medicine · 2026Article
- Circulating immune cell phenotypes are associated with inflammatory biomarkers in dementia-free participants from the Framingham Heart Study Offspring cohort.Scientific reports · 2026Article
- Review
- Association of circulating immune cell phenotypes and peripheral inflammatory biomarkers with depressive symptoms in the Framingham Heart Study.Psychoneuroendocrinology · 2026Article
- Correlation Between the Proportion of Senescence-Associated β-Galactosidase-Stained CD8+ T Cells and Age: A Cross-Sectional Study in Japan.International journal of molecular sciences · 2025Article
- Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study.Alcohol, clinical & experimental research · 2025Article
- The Association of Circulating Immune Cells With Cognitive Function, Brain Imaging, and Incident All-cause and Alzheimer's Dementia: The Framingham Offspring Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Alterations of T Cell Subsets Associated with Sickle Cell Trait.Blood and genomics discovery · 2025Article
- An epigenetic human cytomegalovirus infection score predicts viremia risk in seropositive lung transplant recipients.Epigenetics · 2024Article
- ONDSA: a testing framework based on Gaussian graphical models for differential and similarity analysis of multiple omics networks.Briefings in bioinformatics · 2024Article
- Immune cell phenotypes and mortality in the Framingham Heart Study.Immunity & ageing : I & A · 2024Article
- Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort.Immunity & ageing : I & A · 2024Article
- Aging-Related Immune Cell Phenotypes and Mortality in the Framingham Heart Study.Research square · 2023Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Understanding the composition of circulating immune cells with aging and the underlying biologic mechanisms driving aging may provide molecular targets to slow the aging process and reduce age-related disease. Utilizing cryopreserved cells from 996 Framingham Heart Study (FHS) Offspring Cohort participants aged 40 and older (mean 62 years, 48% female), we report on 116 immune cell phenotypes including monocytes, T-, B-, and NK cells and their subtypes, across age groups, sex, cytomegalovirus (CMV) exposure groups, smoking and other cardiovascular risk factors. The major cellular differences with CMV exposure were higher Granzyme B+ cells, effector cells, and effector-memory re-expressing CD45RA (TEMRA) cells for both CD4+ and CD8+. Older age was associated with lower CD3+ T cells, lower naïve cells and naïve/memory ratios for CD4+ and CD8+. We identified many immune cell differences by sex, with males showing lower naïve cells and higher effector and effector memory cells. Current smokers showed lower pro-inflammatory CD8 cells, higher CD8 regulatory type cells and altered B cell subsets. No significant associations were seen with BMI and other cardiovascular risk factors. Our cross-sectional observations of immune cell phenotypes provide a reference to further the understanding of the complexity of immune cells in blood, an easily accessible tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.