ArticleScience immunology2023
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate.bioRxiv : the preprint server for biology · 2026Article
- Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor costimulatory domains.Nature immunology · 2026Article
- Dynamic gut responses to sepsis uncovered by multi-omics profiling in a rodent model.Communications biology · 2026Article
- A Dapl1Science advances · 2025Article
- Article
- Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma.Nature communications · 2025Article
- Epigenetic control of tissue resident memory T cells.Frontiers in immunology · 2025Review
- Regulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease.Cell communication and signaling : CCS · 2024Review
- MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8Mucosal immunology · 2024Article
- TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response.Journal for immunotherapy of cancer · 2024Article
- Machine Learning Made Easy (MLme): a comprehensive toolkit for machine learning-driven data analysis.GigaScience · 2024Article
- The emerging role of effector functions exerted by tissue-resident memory T cells.Oxford open immunology · 2024Review
- Machine Learning Made Easy (MLme): A Comprehensive Toolkit for Machine Learning-Driven Data Analysis.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 3 countries.
Eric Y HelmDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6128-5204
Tomas ZelenkaDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0003-2753-9754
Valeriu B CismasiuDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.
Shamima IslamDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0001-6946-0492
Leonardo SilvaneDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0003-0799-0644
Beatrice ZittiCentre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.ORCID 0000-0003-4610-7535
Tim D HolmesBroegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway.ORCID 0000-0002-9348-3982
Theodore T DrashanskyDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Alexander J KwiatkowskiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Christine TaoDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Joseph DeanDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0002-0239-3907
Alyssa N ObermayerDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0002-7333-973X
Xianghong ChenDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.
Benjamin G KeselowskyJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-6474-7769
Weizhou ZhangDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-8236-0346
Zhiguang HuoDepartment of Biostatistics, College of Medicine, College of Public Health & Health Professions, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-8032-4392
Liang ZhouDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0002-4644-7903
Brian S SheridanDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-3299-5888
Jose R Conejo-GarciaDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0001-6431-4074
Timothy I ShawDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0002-9316-1924
Yenan T BrycesonCentre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.ORCID 0000-0002-7783-9934
Dorina AvramDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL 33612, USA.ORCID 0000-0003-1254-1122
Moffitt Cancer Center · USUniversity of Florida · USKarolinska University Hospital · SEUniversity of Florida Health · USStony Brook School · USUniversity of Bergen · NO
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MRole of Bcl11b in CD4+ T cells and innate lymphoid cellsR01AI067846 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2007 to 2023
$6.2MRegulation of Gut Innate Lymphoid Cells by AhrR01AI132391 · NIAID · UNIVERSITY OF FLORIDA · PI Liang Zhou · 2017 to 2026
$4.8MRole of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue HomeostasisR01AI157109 · NIAID · UNIVERSITY OF FLORIDA · PI ZHOU, LIANG · 2021 to 2025
$2.8MTolerogenic dual microparticle system for treatment of multiple sclerosisR01AI133623 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA, KESELOWSKY, BENJAMIN GEORGE · 2017 to 2021
$2.6MNCI NIH HHS P30 CA076292NIAID NIH HHS R01 AI067846NIAID NIH HHS R01 AI132391NIAID NIH HHS R01 AI133623NIAID NIH HHS R01 AI157109
Abstract
The networks of transcription factors (TFs) that control intestinal-resident memory CD8
Indexed as
CD8-Positive T-LymphocytesTranscription FactorsAnimalsCell DifferentiationIntestinesMiceRepressor ProteinsTumor Suppressor ProteinsBcl11b protein, mouseRepressor ProteinsTranscription FactorsTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.