Evidence map›Paper›PMID 37115776›Full record

ArticlePloS one2023

Clinical predictors of mortality in patients with pseudomonas aeruginosa infection.

Jim Abi Frem, George Doumat, Jamil Kazma, Amal Gharamti, Souha S Kanj, Antoine G Abou Fayad, Ghassan M Matar, Zeina A Kanafani

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

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  17. Identification ofVeterinary world · 2024
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jim Abi FremDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
George DoumatDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.ORCID 0000-0003-3931-2709
Jamil KazmaDepartment of Obstetrics & Gynecology, George Washington University School of Medicine, Washington, District of Columbia, United States of America.
Amal GharamtiDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Souha S KanjDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Antoine G Abou FayadDepartment of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, Lebanon.
Ghassan M MatarDepartment of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, Lebanon.
Zeina A KanafaniDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.ORCID 0000-0001-8814-1286
American University of Beirut · LBGeorge Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfections caused by Pseudomonas aeruginosa are difficult to treat with a significant cost and burden. In Lebanon, P. aeruginosa is one of the most common organisms in ventilator-associated pneumonia (VAP). P. aeruginosa has developed widespread resistance to multiple antimicrobial agents such as fluoroquinolones and carbapenems. We aimed at identifying risk factors associated for P. aeruginosa infections as well as identifying independent risk factors for developing septic shock and in-hospital mortality.

methodsWe used a cross-sectional study design where we included patients with documented P. aeruginosa cultures who developed an infection after obtaining written consent. Two multivariable regression models were used to determine independent predictors of septic shock and mortality.

resultsDuring the observed period of 30 months 196 patients were recruited. The most common predisposing factor was antibiotic use for more than 48 hours within 30 days (55%). The prevalence of multi-drug resistant (MDR) P. aeruginosa was 10%. The strongest predictors of mortality were steroid use (aOR = 3.4), respiratory failure (aOR = 7.3), identified respiratory cultures (aOR = 6.0), malignancy (aOR = 9.8), septic shock (aOR = 18.6), and hemodialysis (aOR = 30.9).

conclusionUnderstanding resistance patterns and risk factors associated with mortality is crucial to personalize treatment based on risk level and to decrease the emerging threat of antimicrobial resistance.

Indexed as

Pneumonia, Ventilator-AssociatedPseudomonas InfectionsShock, SepticAnti-Bacterial AgentsCross-Sectional StudiesDrug Resistance, Multiple, BacterialHumansPseudomonas aeruginosaRetrospective StudiesAnti-Bacterial Agents

Identifiers

PMID37115776
PMCPMC10146515
OpenAlexW4367309352

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.