ArticleThe Journal of urology2023
Aquablation Therapy in Large Prostates (80-150 mL) for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Final WATER II 5-Year Clinical Trial Results.
Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03123250 (Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue II), which is not on this map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue II
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The median lobe scenario. How to tackle this challenge best: systematic review and expert guidance.World journal of urology · 2026Pooled it
- Aquablation versus laser enucleation of the prostate for benign prostatic hyperplasia: a systematic review and pairwise meta-analysis of head-to-head studies including the first randomized trial.Frontiers in surgery · 2026Pooled it
- Complication Profile and Safety Outcomes of Aquablation in the Management of BPH.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Reintervention rates after minimally invasive benign prostatic hyperplasia therapies: a systematic review including industry involvement.World journal of urology · 2025Pooled it
- Ejaculation sparing of classic and minimally invasive surgical treatments of LUTS/BPH.Prostate cancer and prostatic diseases · 2025Pooled it
- Reoperation after surgical treatment for benign prostatic hyperplasia: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Review
- Two-dimensional computational fluid dynamics study of urine flow in the prostatic fossa after benign prostatic hyperplasia surgery: a single-patient model.Translational andrology and urology · 2026Article
- Phase-specific workflow maturation during early institutional implementation of Aquablation for benign prostatic hyperplasia: a retrospective single-center study.Journal of robotic surgery · 2026Article
- Aquablation/AquaBeam Waterjet Therapy for Benign Prostatic Hyperplasia: Three-Year Functional and Ejaculatory Outcomes in a Multicenter Real-World Italian Cohort.Lower urinary tract symptoms · 2026Article
- Global research landscape of benign prostatic hyperplasia (2010-2026): a bibliometric and visualized analysis revealing evolving trends, hotspots, and future frontiers.World journal of urology · 2026Article
- Aquablation for LUTS due to BPH in men with localized prostate cancer.The Canadian journal of urology · 2026Article
- Aquablation for dual burden disease - BPH and chronic prostatitis/chronic pelvic pain syndrome: a single-center prospective pilot study.BMC urology · 2026Article
- Editorial Comments to "Optimizing Patient Selection for Aquablation During the Initial Adoption Phase: Prostates Smaller Than 100 mL".International journal of urology : official journal of the Japanese Urological Association · 2026Article
- Real-World outcomes of aquablation for benign prostatic hyperplasia: a comparative analysis of the international collaborative aquablation research urology society (ICARUS) database, WATER and WATER-II trials.World journal of urology · 2026Article
- A Case Series on the Efficacy and Safety of Transperineal Laser Ablation for Benign Prostatic Hyperplasia.Journal of clinical medicine · 2026Article
- A Narrative Review of Robotic Aquablation in Benign Prostatic Hyperplasia Care: Where We Are Now.Cureus · 2025Review
- Outcomes of aquablation: pooled analysis from the WATER, WATER II, OPEN WATER, FRANCAIS WATER, and JAPAN PMS studies.World journal of urology · 2025Article
- Aquablation versus HoLEP: Propensity score matching analysis of functional outcomes and ejaculation preservation.Investigative and clinical urology · 2025Article
- Application of robotics in the treatment of benign prostatic hyperplasia: a narrative review.Prostate international · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 13 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe report 5-year safety and efficacy outcomes of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia and large-volume prostate glands. MATERIALS AND
methodsA total of 101 men with moderate to severe benign prostatic hyperplasia symptoms and prostate volumes between 80 and 150 mL underwent a robotic-assisted Aquablation procedure in a prospective multicenter international trial (NCT03123250). Herein we report the final 5-year results.
resultsThe study successfully met its safety and efficacy performance goal, which was based upon transurethral resection of the prostate outcomes typically done in smaller prostates, at 3 months. Mean prostate volume was 107 mL (range 80-150) at baseline. Patient symptoms showed a significant improvement where the mean (SD) International Prostate Symptom Score of 22.6 (6.4) at baseline to 6.8 (4.6) at 5 years, resulting in a change score of 15.9 (7.7,
conclusionsAt 5-years of prospective follow-up, the Aquablation procedure was shown to be safe with durable efficacy and low rates of retreatment in men with large prostates (80-150 mL).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.