ArticlePlant biotechnology journal2023
Evolution-guided multiomics provide insights into the strengthening of bioactive flavone biosynthesis in medicinal pummelo.
Article in Plant biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
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- Highly heterozygous Citrus changshan-huyou Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue-specific allelic imbalance.The plant genome · 2026Article
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- Integrated Omics Analysis Revealed the Differential Metabolism of Pigments in Three Varieties ofInternational journal of molecular sciences · 2025Article
- A chromosome-level genome assembly of Alpinia officinarum Hance sheds new light on its evolution and flavonoid biosynthesis.Molecular horticulture · 2025Article
- Genome-wide identification and expression profiles of NAC transcription factors in Poncirus trifoliata reveal their potential roles in cold tolerance.BMC plant biology · 2025Article
- Citrus genomes: past, present and future.Horticulture research · 2025Article
- "Candidatus Liberibacter asiaticus" Infection Induces Citric Acid Accumulation and Immune Responses Mediated by the Transcription Factor CitPH4.Molecular plant pathology · 2025Article
- Analysis of Volatile Compounds inMolecules (Basel, Switzerland) · 2025Article
- The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production.Metabolites · 2024Review
- Widely Targeted Metabolomics Reveal the Distribution of Metabolites in Shatian Pomelo Fruit.Foods (Basel, Switzerland) · 2024Article
- Metabolic profile and bioactivity of the peel of Zhoupigan (Food chemistry: X · 2024Article
- The genomes of Australian wild limes.Plant molecular biology · 2024Article
- Four novelHorticulture research · 2024Article
- Metabolomics to understand metabolic regulation underpinning fruit ripening, development, and quality.Journal of experimental botany · 2024Review
- A metabolomics study in citrus provides insight into bioactive phenylpropanoid metabolism.Horticulture research · 2024Article
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Authors and funding
23 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pummelo (Citrus maxima or Citrus grandis) is a basic species and an important type for breeding in Citrus. Pummelo is used not only for fresh consumption but also for medicinal purposes. However, the molecular basis of medicinal traits is unclear. Here, compared with wild citrus species/Citrus-related genera, the content of 43 bioactive metabolites and their derivatives increased in the pummelo. Furthermore, we assembled the genome sequence of a variety for medicinal purposes with a long history, Citrus maxima 'Huazhouyou-tomentosa' (HZY-T), at the chromosome level with a genome size of 349.07 Mb. Comparative genomics showed that the expanded gene family in the pummelo genome was enriched in flavonoids-, terpenoid-, and phenylpropanoid biosynthesis. Using the metabolome and transcriptome of six developmental stages of HZY-T and Citrus maxima 'Huazhouyou-smooth' (HZY-S) fruit peel, we generated the regulatory networks of bioactive metabolites and their derivatives. We identified a novel MYB transcription factor, CmtMYB108, as an important regulator of flavone pathways. Both mutations and expression of CmtMYB108, which targets the genes PAL (phenylalanine ammonia-lyase) and FNS (flavone synthase), displayed differential expression between Citrus-related genera, wild citrus species and pummelo species. This study provides insights into the evolution-associated changes in bioactive metabolism during the origin process of pummelo.
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