Evidence map›Paper›PMID 37114757›Full record

ArticleJournal of developmental origins of health and disease2023

Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.

Alicia White, Jane Stremming, Laura D Brown, Paul J Rozance

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of developmental origins of health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alicia WhiteDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-1829-8346
Jane StremmingDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Laura D BrownDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Paul J RozanceDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Training Program in Perinatal Biology and MedicineT32HD007186 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 1985 to 2026
$6.5M
Nutrient Coordination of Pancreatic Vasculature and Beta-CellsR01DK088139 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ROZANCE, PAUL JOSEPH · 2011 to 2020
$5.1M
Regulation of Fetal Skeletal Muscle Growth in IUGRR01HD079404 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Laura Davidson Brown · 2015 to 2026
$4.7M
Physiological Ramifications of Chorionic Somatomammotropin DeficiencyR01HD093701 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANTHONY, RUSSELL V, ROZANCE, PAUL JOSEPH · 2018 to 2022
$2.9M
Fetal glucagon links fetal metabolism with uterine blood flow and placental nutrient transfer by inhibiting placental lactogen secretionR01HD111557 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 2023 to 2026
$2.5M
UV-visible HPLC with PCX Pinnacle post column reaction moduleS10OD023553 · OD · UNIVERSITY OF COLORADO DENVER · PI BROWN, LAURA DAVIDSON · 2017 to 2017
$98k
NICHD NIH HHS R01 HD079404NICHD NIH HHS R01 HD093701NICHD NIH HHS R01 HD111557NICHD NIH HHS T32 HD007186NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK088139NIH HHS S10 OD023553
6 · The paper itself

Abstract

Insulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces

Indexed as

GlucoseInsulin-Like Growth Factor IAnimalsFemaleFetusInsulinInsulin SecretionPregnancySheepGlucoseInsulinInsulin-Like Growth Factor Ifetusglucose-stimulated insulin secretioninsulin-like growth factorβ-cell

Identifiers

PMID37114757
PMCPMC10205682
OpenAlexW4367319440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.