Evidence map›Paper›PMID 37114092›Full record

ArticleMaterials today. Bio2023

Incorporation of synthetic water-soluble curcumin polymeric drug within calcium phosphate cements for bone defect repairing.

Ying Zhang, Hailiang Xu, Jing Wang, Xiaochen Fan, Fang Tian, Zhiyuan Wang, Botao Lu, Weidong Wu, Youjun Liu, Yixiang Ai and 4 more

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ying ZhangDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Hailiang XuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Jing WangScience and Technology on Thermostructural Composite Materials Laboratory, Northwestern Polytechnical University, Xi'an, China.
Xiaochen FanDepartment of Chinese Medicine and Rehabilitation, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Fang TianDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Zhiyuan WangDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Botao LuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Weidong WuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Youjun LiuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Yixiang AiDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Xiaohui WangDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Lei ZhuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Shuaijun JiaDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Dingjun HaoDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Xi'an Honghui Hospital · CNNorthwestern Polytechnical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modified macroporous structures and active osteogenic substances are necessary to overcome the limited bone regeneration capacity and low degradability of self-curing calcium phosphate cement (CPC). Curcumin (CUR), which possesses strong osteogenic activity and poor aqueous solubility/bioavailability, esterifies the side chains in hyaluronic acid (HA) to form a water-soluble CUR-HA macromolecule. In this study, we incorporated the CUR-HA and glucose microparticles (GMPs) into the CPC powder to fabricate the CUR-HA/GMP/CPC composite, which not only retained the good injectability and mechanical strength of bone cements, but also significantly increased the cement porosity and sustained release property of CUR-HA

Indexed as

Bone defectsCalcium phosphate cementCurcuminHyaluronic acidOsteogenic activity

Identifiers

PMID37114092
PMCPMC10127129
OpenAlexW4362696074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.