Evidence map›Paper›PMID 37114047›Full record

ArticleFrontiers in immunology2023

DNA immunization with

Gry Persson, Katherine H Restori, Julie Hincheli Emdrup, Sophie Schussek, Michael Schantz Klausen, McKayla J Nicol, Bhuvana Katkere, Birgitte Rønø, Girish Kirimanjeswara, Anders Bundgaard Sørensen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Gry PerssonEvaxion Biotech A/S, Hoersholm, Denmark.
Katherine H RestoriDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
Julie Hincheli EmdrupEvaxion Biotech A/S, Hoersholm, Denmark.
Sophie SchussekEvaxion Biotech A/S, Hoersholm, Denmark.
Michael Schantz KlausenEvaxion Biotech A/S, Hoersholm, Denmark.
McKayla J NicolDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
Bhuvana KatkereDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
Birgitte RønøEvaxion Biotech A/S, Hoersholm, Denmark.
Girish KirimanjeswaraDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, United States.
Anders Bundgaard SørensenEvaxion Biotech A/S, Hoersholm, Denmark.
Pennsylvania State University · US

Funding

Regulation of B cells by SeleniumR01AI123521 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI KIRIMANJESWARA, GIRISH S · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI123521
6 · The paper itself

Abstract

The global SARS-CoV-2 pandemic caused significant social and economic disruption worldwide, despite highly effective vaccines being developed at an unprecedented speed. Because the first licensed vaccines target only single B-cell antigens, antigenic drift could lead to loss of efficacy against emerging SARS-CoV-2 variants. Improving B-cell vaccines by including multiple T-cell epitopes could solve this problem. Here, we show that

Indexed as

COVID-19Vaccines, DNAAngiotensin-Converting Enzyme 2AnimalsDNAEpitopes, T-Lymphocytegamma-GlobulinsImmunizationMelphalanMiceSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2DNAEpitopes, T-Lymphocytegamma-GlobulinsK-18 conjugateMelphalanVaccines, DNACOVID-19machine learningSARS-CoV-2T-cell vaccineviral challenge model

Identifiers

PMID37114047
PMCPMC10126292
OpenAlexW4364368466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.