Evidence map›Paper›PMID 37114041›Full record

ArticleFrontiers in immunology2023

An exploratory study investigating the effect of targeted hyperoxemia in a randomized controlled trial in a long-term resuscitated model of combined acute subdural hematoma and hemorrhagic shock in cardiovascular healthy pigs.

Thomas Datzmann, Franziska Münz, Andrea Hoffmann, Elena Moehrke, Martha Binzenhöfer, Michael Gröger, Thomas Kapapa, René Mathieu, Simon Mayer, Fabian Zink and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Thomas DatzmannInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Franziska MünzInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Andrea HoffmannInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Elena MoehrkeInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Martha BinzenhöferInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Michael GrögerInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Thomas KapapaDepartment of Neurosurgery, University Hospital Ulm, Ulm, Germany.
René MathieuDepartment of Neurosurgery, German Federal Armed Forces Hospital Ulm, Ulm, Germany.
Simon MayerDepartment of Neurosurgery, German Federal Armed Forces Hospital Ulm, Ulm, Germany.
Fabian ZinkInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Holger GässlerDepartment of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, German Armed Forces Hospital Ulm, Ulm, Germany.
Eva-Maria WolfschmittInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Melanie HoggInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Tamara MerzInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Enrico CalziaInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Peter RadermacherInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
David Alexander Christian MessererInstitute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe physical injuries and associated traumatic brain injury and/or hemorrhagic shock (HS) remain leading causes of death worldwide, aggravated by accompanying extensive inflammation. Retrospective clinical data indicated an association between mild hyperoxemia and improved survival and outcome. However, corresponding prospective clinical data, including long-term resuscutation, are scarce. Therefore, the present study explored the effect of mild hyperoxemia for 24 hours in a prospective randomized controlled trial in a long-term resuscitated model of combined acute subdural hematoma (ASDH) and HS. ASDH was induced by injecting 0.1 ml × kg

Indexed as

Hematoma, Subdural, AcuteShock, HemorrhagicAnimalsInflammationProspective StudiesRetrospective StudiesSwinehemorrhagic shockhyperoxemiamultimodal brain monitoringradical oxygen speciestraumatic brain injury

Identifiers

PMID37114041
PMCPMC10126345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.