ReviewInternational journal of exercise science2023
The Effects of Anabolic-Androgenic Steroids on Gene Expression in Skeletal Muscle: A Systematic Review.
Review in International journal of exercise science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- The effects of anabolic-androgenic steroid use and training style on myogenic expression in trained male iron sport athletes.European journal of applied physiology · 2026Article
- Anabolic androgenic steroids and illicit drugs as potential modulating factors in malignant hyperthermia: a case series.Anaesthesiology intensive therapy · 2025Article
- Skeletal Muscle Memory: An Update From the Antidoping Perspective.Drug testing and analysis · 2025Review
- Challenging the principle of "No presumption of advantage" with a focus on testosterone and gender eligibility in sports.Frontiers in sports and active living · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anabolic-androgenic steroids (AAS) act via androgen receptor (AR) interaction to induce muscle protein synthesis. This process is achieved via altered gene expression via the Notch, Wnt, and Numb pathways and their interactions at the AR, manifesting in key skeletal muscle (SM) phenotypes such as morphology, ion conductance, and functionality. This review aims to report on the effects of AAS administration on gene expression in SM. Peer-reviewed empirical studies evaluating AAS administration on SM phenotypes and gene expression were considered for inclusion. The following databases were searched using a data range of Jan 2000-November 2020: MEDLINE Complete, Academic Search Complete, APA PsycInfo, SPORTDiscus, CINAHL Plus, Cochrane Central Register of Controlled Trials, Rehabilitation & Sports Medicine Source, GreenFILE, and APA PsycArticles. Potential risks of bias were assessed via a modified PEDro Scale. Twenty-nine peer-reviewed titles were included. All studies consisted of either human or rodent subjects and included an AAS dosing protocol, investigated SM phenotypes, and measured gene expression as an outcome variable. Studies investigated the effects of eight AAS compounds across a total of 88 different genes in SM. The most commonly identified genes increased by AAS were IGF, MYOG, and MyoD. There was a general lack of standardized dosing and AAS variety. Future studies should attempt to incorporate multiple AAS compounds and their effects on key SM gene expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.