Evidence map›Paper›PMID 37113617›Full record

ArticleAJOG global reports2023

Humoral immune response to SARS-CoV-2 in pregnant and nonpregnant women following infection.

Marni B Jacobs, Holly D Valentine, Sierra Adkins, Celestine Magallanes, Sydney C Morgan, Lissa M Pereira, Chandana Tekkatte, Abbas Hakim, Peter De Hoff, Louise C Laurent and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJOG global reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Immune Response to Respiratory Viral Infections.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marni B JacobsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Holly D ValentineDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Sierra AdkinsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Celestine MagallanesDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Sydney C MorganDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Lissa M PereiraDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Chandana TekkatteDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Abbas HakimDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Peter De HoffDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Louise C LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).
Priyadarshini PanthamDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, CA (Dr Jacobs, Mses Valentine, Adkins, and Magallanes, Dr Morgan, Mses Pereira and Tekkatte, Mr Hakim, and Drs Dehoff, Laurent, and Pantham).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune changes that occur during pregnancy may place pregnant women at an increased risk for severe disease following viral infections like SARS-CoV-2. Whether these immunologic changes modify the immune response to SARS-CoV-2 infection during pregnancy is not well understood.

objectiveThis study aimed to compare the humoral immune response to SARS-CoV-2 infection in pregnant and nonpregnant women. The immune response following vaccination for SARS-CoV-2 was also explored. STUDY

designIn this cohort study, 24 serum samples from 20 patients infected with SARS-CoV-2 during pregnancy were matched by number of days after a positive test with 46 samples from 40 nonpregnant women of reproductive age. Samples from 9 patients who were vaccinated during pregnancy were also examined. Immunoglobulin G and immunoglobulin M levels were measured. Trends in the log antibody levels over time and mean antibody levels were assessed using generalized estimating equations.

resultsThe median number of days from first positive test to sampling was 6.5 in the pregnant group (range, 3-97) and 6.0 among nonpregnant participants (range, 2-97). No significant differences in demographic or sampling characteristics were noted between the groups. No differences in immunoglobulin G or immunoglobulin M levels over time or mean antibody levels were noted among pregnant and nonpregnant participants following SARS-CoV-2 infection for any of the SARS-CoV-2 antigen targets examined (spike, spike receptor-binding domain, spike N-terminal domain, and nucleocapsid). Participants who were vaccinated during pregnancy had higher immunoglobulin G levels than pregnant patients who tested positive for all SARS-CoV-2 targets except nucleocapsid antibodies (all

conclusionThis study suggests that the humoral response following SARS-CoV-2 infection does not seem to differ between pregnant women and their nonpregnant counterparts. These findings should reassure patients and healthcare providers that pregnant patients seem to mount a nondifferential immune response to SARS-CoV-2.

Indexed as

antibodiesCOVID-19immunityimmunoglobulin Gimmunoglobulin Mpregnancyvaccination

Identifiers

PMID37113617
PMCPMC10010833

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.