ArticleFrontiers in aging neuroscience2023
Can the fNIRS-derived neural biomarker better discriminate mild cognitive impairment than a neuropsychological screening test?
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Functional near-infrared spectroscopy for identifying mild cognitive impairment and Alzheimer's disease: a systematic review.Frontiers in neurology · 2025Pooled it
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Exploring Cognitive Load and Relative Neural Efficiency in Aging: : Preliminary Insights from fNIRS and the SLUMS Assessment.Delaware journal of public health · 2026Article
- Effects of Baduanjin exercise on working memory in mild cognitive impairment: an fNIRS-based randomized controlled trial.Frontiers in aging neuroscience · 2026Article
- An fNIRS-based investigation of cerebral hemodynamic responses during verbal fluency task and n-back task in individuals with mild cognitive impairment.Frontiers in neurology · 2025Article
- Classification of Mild Cognitive Impairment Using Functional Near-Infrared Spectroscopy-Derived Biomarkers With Convolutional Neural Networks.Psychiatry investigation · 2024Article
- Unveiling Neurocognitive Disparities in Encoding and Retrieval between Paper and Digital Tablet-Based Learning.Brain sciences · 2024Article
- Mental workload classification using convolutional neural networks based on fNIRS-derived prefrontal activity.BMC neurology · 2023Article
- Effects of Personalized Cognitive Training Using Mental Workload Monitoring on Executive Function in Older Adults With Mild Cognitive Impairment.Brain & NeuroRehabilitation · 2023Article
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1 author at 1 institution in 1 country.
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Abstract
Introduction: Early detection of mild cognitive impairment (MCI), a pre-clinical stage of Alzheimer's disease (AD), has been highlighted as it could be beneficial to prevent progression to AD. Although prior studies on MCI screening have been conducted, the optimized detection way remain unclear yet. Recently, the potential of biomarker for MCI has gained a lot of attention due to a relatively low discriminant power of clinical screening tools. Methods: This study evaluated biomarkers for screening MCI by performing a verbal digit span task (VDST) using functional near-infrared spectroscopy (fNIRS) to measure signals from the prefrontal cortex (PFC) from a group of 84 healthy controls and 52 subjects with MCI. The concentration changes of oxy-hemoglobin (HbO) were explored during the task in subject groups. Results: Findings revealed that significant reductions in HbO concentration were observed in the PFC in the MCI group. Specially, the mean of HbO (mHbO) in the left PFC showed the highest discriminant power for MCI, which was higher than that of the Korean version of montreal cognitive assessment (MoCA-K) widely used as a screening tool for MCI. Furthermore, the mHbO in the PFC during the VDST was identified to be significantly correlated to the MoCA-K scores. Discussion: These findings shed new light on the feasibility and superiority of fNIRS-derived neural biomarker for screening MCI.
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