ArticleFrontiers in psychiatry2023
Inequality and barriers in psychosis prevention: A systematic review on clinical high-risk for psychosis studies from developing countries.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Availability and effectiveness of multicomponent interventions for early psychosis in 20 low-income and middle-income countries: a systematic review.EClinicalMedicine · 2026Article
- Screening the Community for Individuals at Clinical High Risk (CHR) for Psychosis.Early intervention in psychiatry · 2025Article
- Are Sociodemographic Characteristics Associated with Course of High Risk for Psychosis Symptoms at 12-Month Follow-Up?Psychology research and behavior management · 2025Article
- Kenya Psychosis-Risk Outcomes Study (KePROS): Development of an Accelerated Medicine Partnership Schizophrenia-Aligned Project in Africa.Schizophrenia bulletin open · 2024Article
- Gesticulation in individuals with at risk mental states for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Editorial: Psychotic experiences and symptoms in adolescents and young adults from different countries and cultural backgrounds.Frontiers in psychiatry · 2023Article
- The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk.Frontiers in psychiatry · 2023Article
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Authors and funding
6 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The clinical high-risk for psychosis (CHR) paradigm is one of the best studied preventive paradigms in psychiatry. However, most studies have been conducted in high-income countries. It is unclear if knowledge from such countries applies to low and middle-income countries (LAMIC), and if there are specific limitations hindering CHR research there. Our aim is to systematically review studies on CHR from LAMIC. Methods: A multistep PRISMA-compliant literature search was performed in PubMed and Web of Science for articles published until 1/03/2022, conducted in LAMIC, addressing the concept and correlates of CHR. Study characteristics as well as limitations were reported. Corresponding authors of the included studies were invited to answer an online poll. Quality assessment was done with the MMAT. Results: A total of 109 studies were included in the review: none from low-income countries, 8 from lower middle-income countries, and 101 from upper middle-income countries. The most frequent limitations were small sample size (47.9%), cross-sectional design (27.1%), and follow-up issues (20.8%). Mean quality of included studies was of 4.4. Out of the 43 corresponding authors, 12 (27.9%) completed the online poll. They cited further limitations as few financial resources (66.7%), no involvement of population (58.2%) and cultural barriers (41.7%). Seventy five percent researchers reported that CHR research should be conducted differently in LAMIC compared to high-income countries, due to structural and cultural issues. Stigma was mentioned in three out of five sections of the poll. Discussion: Results show the discrepancy of available evidence on CHR in LAMIC, given the shortage of resources in such countries. Future directions should aim to increase the knowledge on individuals at CHR in such settings, and to address stigma and cultural factors that may play a role in the pathways toward care in psychosis. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=316816, CRD42022316816.
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