ArticleFrontiers in psychiatry2023
The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Trial
- Functional near-infrared spectroscopy (fNIRS) in medical research: applications, opportunities, and challenges.Chinese medicine · 2026Review
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- Divergent prefrontal activation between genders in depression during verbal fluency task: evidence from a large-scale fNIRS study.Annals of general psychiatry · 2026Article
- Association of simultaneous sour taste stimulation with prefrontal cortex activation during stroop task performance in healthy adults: a fNIRS study.Frontiers in behavioral neuroscience · 2026Article
- Machine Learning Based Identification of Depressive Symptoms Among Students in a Chinese University Using Functional Near-Infrared Spectroscopy.Alpha psychiatry · 2025Article
- Clinical value of predicting relapse within 3 months in alcohol-dependent patients using fNIRS in verbal fluency task.Scientific reports · 2025Article
- Cortical network characteristics in post-stroke anxiety: an fNIRS-based study.Frontiers in neuroscience · 2025Article
- Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2025Article
- fNIRS evidence of abnormal frontotemporal cortex activation and functional connectivity in depressed patients after stroke: neuromodulatory mechanisms from mild to moderate depression.Frontiers in neurology · 2025Article
- Functional near-infrared spectroscopy-based diagnosis support system for distinguishing between mild and severe depression using machine learning approaches.Neurophotonics · 2024Article
- A scoping review of utilization of the verbal fluency task in Chinese and Japanese clinical settings with near-infrared spectroscopy.Frontiers in psychiatry · 2024Article
- A free association semantic task for fNIRS-based perinatal depression assessment.Frontiers in neurology · 2024Article
- Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study.NeuroRehabilitation · 2024Article
- Distinct resting-state effective connectivity of large-scale networks in first-episode and recurrent major depression disorder: evidence from the REST-meta-MDD consortium.Frontiers in neuroscience · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Functional near-infrared spectroscopy (fNIRS) identifies neurophysiological differences between psychiatric disorders by assessing cortical hemodynamic function. Few trials have studied differences in brain functional activity between first-episode medication-naïve depression patients (FMD) and recurrent major depression (RMD). We aimed to determine the differences between FMD and RMD in oxygenated hemoglobin concentration ([oxy-Hb]), and to investigate the correlation between frontotemporal cortex activation and clinical symptoms. Methods: We recruited 40 patients with FMD, 53 with RMD, and 38 healthy controls (HCs) from May 2021 to April 2022. Symptom severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). A 52-channel fNIRS measured changes in [oxy-Hb] during VFT performance. Results: Both patient groups performed poorly during the VFT task compared with HC (FDR Conclusion: The presence of different neurofunctional activity in some of the same brain regions in FMD and RMD patients implied a link between the level of complexity activation in frontal regions and the stage of MDD. Cognitive impairment may already be present at the beginning of an MDD episode. Clinical trial registration: www.chictr.org.cn, identifier ChiCTR2100043432.
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