Evidence map›Paper›PMID 37113534›Full record

ArticleClinical parkinsonism & related disorders2023

Plantar Grasp sign as a screening tool for Orthostatic Tremor (OT).

Rebecca Thompson, Danish Bhatti, Kalyan Malgireddy, Venkata Sunil Bendi, John M Bertoni, Vekash Raja, Diego Torres-Russotto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rebecca ThompsonDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
Danish BhattiDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
Kalyan MalgireddyDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
Venkata Sunil BendiDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
John M BertoniDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
Vekash RajaDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
Diego Torres-RussottoDepartment of Neurological Sciences - Division of Movement Disorders, University of Nebraska Medical Center, 988435 Nebraska Medical Center, Omaha, NE 68198-8435, United States.
Nebraska Medical Center · USDartmouth–Hitchcock Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Orthostatic tremor (OT) is a rare neurological disorder characterized by a sensation of instability while standing. Very few clinical signs have been described for OT to date. Finding other symptoms and signs could prove valuable for this hard-to-recognized disease. Methods: This protocol is part of the University of Nebraska Medical Center Orthostatic Tremor longitudinal study. It was noted that OT patients flex their toes and sometimes the foot arch while standing (Plantar Grasp). They reported doing this to "grab" the floor and improve stability. This paper analyses the diagnostic test characteristics of the patient-self-reported Plantar Grasp, a new sign in OT. Results: There were 34 OT patients (88% females), and 20 controls (65% females). Eighty-eight percent of patients with OT reported the plantar grasp sign and none of the controls. The Plantar Grasp Sign was found to be very sensitive (88%), and extremely specific (100%) in our cohort. Non-weighted Negative Likelihood Ratio (NLR) was 0.12. And the 3% prevalence-weighted NLR was so low that the negative post-test probability was close to zero. Conclusion: Due to its high sensitivity, specificity, and ideal likelihood ratio, we propose that the Plantar Grasp sign could be considered to screen patients with possible OT. Further studies are needed to determine the specificity of this sign in OT versus other balance disorders.

Indexed as

Orthostatic tremorPlantar Grasp signScreening toolSensitivity and specificity

Identifiers

PMID37113534
PMCPMC10126904
OpenAlexW4362453316

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.