Evidence map›Paper›PMID 37113136›Full record

ArticleFrontiers in cellular and infection microbiology2023

Anti-Cholera toxin activity of selected polyphenols from

Rajitha Charla, Priyanka P Patil, Vishal S Patil, Vishwambhar V Bhandare, Veeresh Karoshi, Venkanna Balaganur, Rajesh K Joshi, Darasaguppe R Harish, Subarna Roy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Protective Role ofMicroorganisms · 2025
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rajitha CharlaIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Priyanka P PatilIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Vishal S PatilIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Vishwambhar V BhandareIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Veeresh KaroshiIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Venkanna BalaganurIndian Council of Agricultural Research - Krishi Vigyan Kendra, Bagalkot, Karnataka, India.
Rajesh K JoshiIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Darasaguppe R HarishIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Subarna RoyIndian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Indian Council of Medical Research · INKLE University · INUniversity of Agricultural Sciences, Dharwad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Molecular modelling approach was used to investigate the intermolecular interactions of selected 20 polyphenolic compounds from three plants with CT using DOCK6. Based on intermolecular interactions, two phenolic acids, Ellagic acid (EA) and Chlorogenic acid (CHL); two flavonoids, Rutin (RTN) and Phloridzin (PHD) were selected along with their respective standards, Gallic acid (GA) and Quercetrin (QRTN). The stability of docked complexes was corroborated using molecular dynamics simulation. Furthermore, in vitro inhibitory activity of six compounds against CT was assessed using GM1 ELISA and cAMP assay. EA and CHL that showed prominent activity against CT in Results and discussion: The molecular modelling study revealed significant structural stability of the CT-EA, CT-CHL, and CT-PHD complexes compared to their respective controls. All the selected six compounds significantly reduced CT-induced cAMP levels, whereas EA, CHL, and PHD exhibited > 50% binding inhibition of CT to GM1. The EA and CHL that showed prominent neutralization activity against CT from

Indexed as

CholeraPomegranatePsidiumAnimalsCholera ToxinDiarrheaG(M1) GangliosideMicePolyphenolsCholera ToxinG(M1) GangliosidePolyphenolscell free culture filtrateCholera toxincytotoxicitydockingGM1 ELISAmolecular dynamics simulations

Identifiers

PMID37113136
PMCPMC10126245
OpenAlexW4364368770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.