Evidence map›Paper›PMID 37112962›Full record

ArticleViruses2023

Intrahost Genetic Diversity of Dengue Virus in Human Hosts and Mosquito Vectors under Natural Conditions Which Impact Replicative Fitness

Patcharaporn Nonyong, Tipaya Ekalaksananan, Supranee Phanthanawiboon, Hans J Overgaard, Neal Alexander, Kesorn Thaewnongiew, Vorthon Sawaswong, Pattaraporn Nimsamer, Sunchai Payungporn, Juthamas Phadungsombat and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Tracing Dengue's Evolutionary and Phylogenetic Pathways.Current topics in microbiology and immunology · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Patcharaporn NonyongDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Tipaya EkalaksanananDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-2406-2356
Supranee PhanthanawiboonDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Hans J OvergaardFaculty of Science and Technology, Norwegian University of Life Sciences, P.O. Box 5003, 1432 Ås, Norway.ORCID 0000-0001-7604-3785
Neal AlexanderMRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0002-6707-7876
Kesorn ThaewnongiewDepartment of Disease Control, Office of Disease Prevention and Control, Region 7 Khon Kaen, Ministry of Public Health, Khon Kaen 40000, Thailand.
Vorthon SawaswongProgram in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
Pattaraporn NimsamerCenter of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Sunchai PayungpornCenter of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Juthamas PhadungsombatMahidol-Osaka Center for Infectious Diseases (MOCID), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0001-6739-0144
Emi E NakayamaMahidol-Osaka Center for Infectious Diseases (MOCID), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-0477-0980
Tatsuo ShiodaMahidol-Osaka Center for Infectious Diseases (MOCID), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-3439-8331
Chamsai PientongDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-2797-043X
Khon Kaen University · THChulalongkorn University · THMahidol University · THLondon School of Hygiene & Tropical Medicine · GBMinistry of Public Health · THNorwegian University of Life Sciences · NO

Funding

Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

Dengue virus (DENV) is an arbovirus whose transmission cycle involves disparate hosts: humans and mosquitoes. The error-prone nature of viral RNA replication drives the high mutation rates, and the consequently high genetic diversity affects viral fitness over this transmission cycle. A few studies have been performed to investigate the intrahost genetic diversity between hosts, although their mosquito infections were performed artificially in the laboratory setting. Here, we performed whole-genome deep sequencing of DENV-1 (

Indexed as

AedesDengueDengue VirusAnimalsGenetic VariationHumansMosquito VectorsAedes aegyptidengue virushost switchingintrahost genetic diversityreplication kineticsselection pressure

Identifiers

PMID37112962
PMCPMC10143933
OpenAlexW4366189082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.