Evidence map›Paper›PMID 37112903›Full record

ArticleViruses2023

Identification of B-Cell Linear Epitopes in the Nucleocapsid (N) Protein B-Cell Linear Epitopes Conserved among the Main SARS-CoV-2 Variants.

Rodrigo N Rodrigues-da-Silva, Fernando P Conte, Gustavo da Silva, Ana L Carneiro-Alencar, Paula R Gomes, Sergio N Kuriyama, Antonio A F Neto, Josué C Lima-Junior

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rodrigo N Rodrigues-da-SilvaLaboratory of Immunological Technology, Institute of Technology in Immunobiologicals, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-9772-849X
Fernando P ConteEukaryotic Pilot Laboratory, Institute of Technology in Immunobiologicals, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-1754-5870
Gustavo da SilvaLaboratory of Immunological Technology, Institute of Technology in Immunobiologicals, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.
Ana L Carneiro-AlencarLaboratory of Immunological Technology, Institute of Technology in Immunobiologicals, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.
Paula R GomesGetulio Vargas State Hospital, Rio de Janeiro 21070-061, Brazil.
Sergio N KuriyamaSENAI Innovation Institute for Green Chemistry, Rio de Janeiro 20271-030, Brazil.
Antonio A F NetoSENAI Innovation Institute for Green Chemistry, Rio de Janeiro 20271-030, Brazil.
Josué C Lima-JuniorLaboratory of Immunoparasitology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-5848-404X
Instituto de Tecnologia e Pesquisa · BRFundação Oswaldo Cruz · BRServiço Nacional de Aprendizagem Industrial · BRFundação Getulio Vargas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Nucleocapsid (N) protein is highlighted as the main target for COVID-19 diagnosis by antigen detection due to its abundance in circulation early during infection. However, the effects of the described mutations in the N protein epitopes and the efficacy of antigen testing across SARS-CoV-2 variants remain controversial and poorly understood. Here, we used immunoinformatics to identify five epitopes in the SARS-CoV-2 N protein (N

Indexed as

Common ColdCOVID-19Middle East Respiratory Syndrome CoronavirusCOVID-19 TestingEpitopes, B-LymphocyteHumansNucleocapsidReceptors, FcSARS-CoV-2Spike Glycoprotein, CoronavirusEpitopes, B-LymphocyteIgA receptorReceptors, FcSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antigen testCOVID-19immunoinformaticSARS-CoV-2 variants

Identifiers

PMID37112903
PMCPMC10145278
OpenAlexW4362670644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.