Evidence map›Paper›PMID 37112866›Full record

ArticleViruses2023

Thrombophilia and Immune-Related Genetic Markers in Long COVID.

Rosilene da Silva, Kevin Matheus Lima de Sarges, Marcos Henrique Damasceno Cantanhede, Flávia Póvoa da Costa, Erika Ferreira Dos Santos, Fabíola Brasil Barbosa Rodrigues, Maria de Nazaré do Socorro de Almeida Viana, Mauro de Meira Leite, Andréa Luciana Soares da Silva, Mioni Thieli Magalhães de Brito and 10 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Cellular Metabolic Signatures of Long COVID-19.Infectious disease reports · 2026
    Article
  3. Article
  4. Long COVID-19: A Concept Analysis.Infectious disease reports · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Association of theViruses · 2024
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Rosilene da SilvaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0001-8913-2971
Kevin Matheus Lima de SargesLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0003-0776-6212
Marcos Henrique Damasceno CantanhedeLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0003-2263-8403
Flávia Póvoa da CostaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0002-5667-0754
Erika Ferreira Dos SantosLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0001-9188-1066
Fabíola Brasil Barbosa RodriguesLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0002-4294-4099
Maria de Nazaré do Socorro de Almeida VianaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.
Mauro de Meira LeiteLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0002-3620-3470
Andréa Luciana Soares da SilvaLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0003-4299-0252
Mioni Thieli Magalhães de BritoLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0001-8165-8629
Maria Karoliny da Silva TorresGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0002-5894-304X
Maria Alice Freitas QueirozGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0003-2014-2770
Izaura Maria Vieira Cayres VallinotoGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 58255-000, Brazil.
Daniele Freitas HenriquesSection of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Secretary of Health Surveillance, Ministry of Health of Brazil, Ananindeua 67000-000, Brazil.
Carla Pinheiro Dos SantosSection of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Secretary of Health Surveillance, Ministry of Health of Brazil, Ananindeua 67000-000, Brazil.
Giselle Maria Rachid VianaGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 58255-000, Brazil.
Juarez Antônio Simões QuaresmaGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0002-6267-9966
Luiz Fábio Magno FalcãoCenter for Biological and Health Sciences, State University of Pará, Belém 58255-000, Brazil.ORCID 0000-0001-8391-2694
Antonio Carlos Rosário VallinotoGraduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0003-1135-6507
Eduardo José Melo Dos SantosLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 58255-000, Brazil.ORCID 0000-0001-5134-5648
Universidade Federal do Pará · BRMinistério da Saúde · BRUniversidade do Estado do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (

Indexed as

COVID-19ThrombophiliaCase-Control StudiesCross-Sectional StudiesGene FrequencyGenetic MarkersGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePost-Acute COVID-19 SyndromeGenetic MarkersIFNGlong COVIDMTHFRpolymorphismsrisk factor

Identifiers

PMID37112866
PMCPMC10143911
OpenAlexW4361275353

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.