Evidence map›Paper›PMID 37112842›Full record

ArticleViruses2023

The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions.

Bharathiraja Subramaniyan, Sunam Gurung, Manish Bodas, Andrew R Moore, Jason L Larabee, Darlene Reuter, Constantin Georgescu, Jonathan D Wren, Dean A Myers, James F Papin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Bharathiraja SubramaniyanDepartment of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Sunam GurungDepartment of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Manish BodasDepartment of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Andrew R MooreDepartment of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Jason L LarabeeDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Darlene ReuterDivision of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Constantin GeorgescuGenes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Jonathan D WrenGenes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Dean A MyersDepartment of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
James F PapinDivision of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0001-9894-8243
Matthew S WaltersDepartment of Medicine, Section of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0003-0010-8444
University of Oklahoma Health Sciences Center · USOklahoma Medical Research Foundation · US

Funding

Vertical Transmission of Zika Virus in Pregnant Olive Baboons FollowingVaginal InfectionR21HD096240 · NICHD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MYERS, DEAN, PAPIN, JAMES F · 2019 to 2020
$399k
NICHD NIH HHS R21 HD096240
6 · The paper itself

Abstract

The mucociliary airway epithelium lines the human airways and is the primary site of host-environmental interactions in the lung. Following virus infection, airway epithelial cells initiate an innate immune response to suppress virus replication. Therefore, defining the virus-host interactions of the mucociliary airway epithelium is critical for understanding the mechanisms that regulate virus infection, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Non-human primates (NHP) are closely related to humans and provide a model to study human disease. However, ethical considerations and high costs can restrict the use of in vivo NHP models. Therefore, there is a need to develop in vitro NHP models of human respiratory virus infection that would allow for rapidly characterizing virus tropism and the suitability of specific NHP species to model human infection. Using the olive baboon (

Indexed as

COVID-19SARS-CoV-2AnimalsEpithelial CellsHost Microbial InteractionsHumansLungPapioair–liquid interfaceairway epitheliumbaboonCOVID-19immune responseinflammationinnate immunitynon-human primateSARS-CoV-2

Identifiers

PMID37112842
PMCPMC10146425
OpenAlexW4361205897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.