ReviewViruses2023
Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far.
Review in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Maternal-to-Child-Transmission of Human Immunodeficiency Virus in Maternal Preterm Premature Rupture of the Membranes: A Systematic Review.The journal of obstetrics and gynaecology research · 2026Pooled it
- Pregnancy and neonatal outcomes of HIV infection in pregnant women in Iran: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Time-Trend, Regional and National Prevalence of Vertical Transmission of HIV-1 in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Journal of primary care & community healthPooled it
- Impact of point-of-care maternal viral load testing at delivery on vertical HIV transmission risk assessment and neonatal prophylaxis: a cluster randomized trial.Journal of the International AIDS Society · 2025Trial
- Modelling the tail-phase pharmacokinetics of long-acting cabotegravir and rilpivirine from early pregnancy to postpartum at steady state.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Predictors of Exclusive Breastfeeding Amongst Mothers Living With HIV in Sub-Saharan Africa: A Scoping Review.Health science reports · 2026Article
- Caregiver-Mediated Adherence and Perceived Health System Factors Associated with Viral Suppression Among Children Receiving Antiretroviral Therapy in Rural South Africa.International journal of environmental research and public health · 2026Article
- Exploring the pharmacokinetic mechanisms that affect bictegravir exposure during pregnancy.The Journal of antimicrobial chemotherapy · 2026Article
- Impact of maternal HIV infection on pregnancy and labor complication and perinatal health outcomes: a South African retrospective study.Archives of gynecology and obstetrics · 2026Article
- Perspective: Infant Feeding Policies among Women Living with HIV in Latin America and the Caribbean: Should They Be Updated?Advances in nutrition (Bethesda, Md.) · 2026Article
- Midwives' views on implementation of antiretroviral clinical guidelines for the prevention of HIV in a private hospital.Health SA = SA Gesondheid · 2026Article
- Analysis of Risk Factors for High versus Low HIV Exposure in Neonates and Development of a Predictive Nomogram Model.Infection and drug resistance · 2026Article
- A scoping review of mobile health for ART adherence in pregnant and breastfeeding women with HIV in sub-Saharan Africa: preferences, acceptability, and privacy concerns.BMC infectious diseases · 2025Article
- Trends in HIV testing and Seroprevalence among key populations at public health centers in South Korea, 2011-2023: a nationwide analysis.BMC public health · 2025Article
- Premastication-Review of an Infant Feeding Practice and Its Potential Impact on Allergy and Microbiome Development.Allergy · 2025Review
- Review
- HIV and Maternal-Fetal Immunity: Challenges and Strategies for Reducing Vertical Transmission-A Narrative Review.Health science reports · 2025Article
- Drug resistance mutations and phylogenetic analysis of HIV-1 subtypes B and F from mothers and children with vertical transmission.BMC infectious diseases · 2025Article
- The Complex Role of CD8+ T Cells in Placental HIV Infection.European journal of immunology · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
In 1989, one in four (25%) infants born to women living with HIV were infected; by the age of 2 years, there was 25% mortality among them due to HIV. These and other pieces of data prompted the development of interventions to offset vertical transmission, including the landmark Pediatric AIDS Clinical Trial Group Study (PACTG 076) in 1994. This study reported a 67.5% reduction in perinatal HIV transmission with prophylactic antenatal, intrapartum, and postnatal zidovudine. Numerous studies since then have provided compelling evidence to further optimize interventions, such that annual transmission rates of 0% are now reported by many health departments in the US and elimination has been validated in several countries around the world. Despite this success, the elimination of HIV's vertical transmission on the global scale remains a work in progress, limited by socioeconomic factors such as the prohibitive cost of antiretrovirals. Here, we review some of the key trials underpinning the development of guidelines in the US as well as globally, and discuss the evidence through a historic lens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.