Evidence map›Paper›PMID 37112803›Full record

ArticleViruses2023

Combination Antiretroviral Therapy and Immunophenotype of Feline Immunodeficiency Virus.

Jeffrey Kim, Elisa S Behzadi, Mary Nehring, Scott Carver, Shannon R Cowan, Megan K Conry, Jennifer E Rawlinson, Sue VandeWoude, Craig A Miller

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jeffrey KimComparative Medicine Research Unit, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
Elisa S BehzadiDepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0009-0004-8708-6325
Mary NehringDepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Scott CarverSchool of Natural Sciences, University of Tasmania, Hobart, TAS 7001, Australia.ORCID 0000-0002-3579-7588
Shannon R CowanDepartment of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078, USA.
Megan K ConryDepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Jennifer E RawlinsonDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Sue VandeWoudeDepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-9227-1622
Craig A MillerDepartment of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-3638-5665
Colorado State University · USOklahoma State University · USUniversity of Louisville · USUniversity of Tasmania · AU

Funding

ZFC3H1 Regulation of Host Defense and Influenza A Virus PathogenesisP20GM103648 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHENG, YONG · 2013 to 2022
$22.3M
Impacts of antiretroviral therapy on oral cavity homeostasis in an FIV animal modelR21DE029733 · NIDCR · COLORADO STATE UNIVERSITY · PI VANDEWOUDE, SUE · 2020 to 2021
$430k
NIDCR NIH HHS R21 DE029733NIDCR NIH HHS R21DE029733NIGMS NIH HHS P20 GM103648NIGMS NIH HHS P20GM103648
6 · The paper itself

Abstract

Feline Immunodeficiency Virus (FIV) causes progressive immune dysfunction in cats similar to human immunodeficiency virus (HIV) in humans. Although combination antiretroviral therapy (cART) is effective against HIV, there is no definitive therapy to improve clinical outcomes in cats with FIV. This study therefore evaluated pharmacokinetics and clinical outcomes of cART (2.5 mg/kg Dolutegravir; 20 mg/kg Tenofovir; 40 mg/kg Emtricitabine) in FIV-infected domestic cats. Specific pathogen free cats were experimentally infected with FIV and administered either cART or placebo treatments (

Indexed as

Feline Acquired Immunodeficiency SyndromeHIV InfectionsImmunodeficiency Virus, FelineAnimalsAntiretroviral Therapy, Highly ActiveCatsHumansProvirusesantiretroviral therapydolutegraviremtricitabinefeline immunodeficiency virusimmunophenotypelentiviral therapytenofovir disoproxil fumarateviral load

Identifiers

PMID37112803
PMCPMC10146003
OpenAlexW4360858563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.