Designable Poly(methacrylic Acid)/Silver Cluster Ring Arrays as Reflectance Spectroscopy-Based Biosensors for Label-Free Plague Diagnosis.

Chih-Wei Chen, Shih-Hsun Chen, Chih-Feng Huang, Jem-Kun Chen

Open access · goldAbstract read

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Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.6field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chih-Wei ChenDivision of Neurosurgery, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan.

Shih-Hsun ChenDepartment of Mechanical Engineering, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu City 300093, Taiwan.ORCID 0000-0002-5750-6470

Chih-Feng HuangDepartment of Chemical Engineering, i-Center for Advanced Science and Technology (iCAST), National Chung Hsing University, Taichung 40227, Taiwan.ORCID 0000-0002-8062-8708

Jem-Kun ChenDepartment of Materials and Science Engineering, National Taiwan University of Science and Technology, 43, Sec. 4, Keelung Road, Taipei 106, Taiwan.ORCID 0000-0003-3670-6710

National Taiwan University of Science and Technology · TWNational Chung Hsing University · TWNational Yang Ming Chiao Tung University · TW

Funding

National Science and Technology Council 110-2221-E-011-011-MY3

6 · The paper itself

Abstract

A hole array was fabricated via photolithography to wet the bottoms of holes using oxygen plasma. Amide-terminated silane, a water immiscible compound before hydrolysis, was evaporated for deposition on the plasma-treated hole template surface. The silane compound was hydrolyzed along the edges of circular sides of the hole bottom to form a ring of an initiator after halogenation. Poly(methacrylic acid) (PMAA) was grafted from the ring of the initiator to attract Ag clusters (AgCs) as AgC-PMAA hybrid ring (SPHR) arrays via alternate phase transition cycles. The SPHR arrays were modified with a Yersinia pestis antibody (abY) to detect the antigen of Yersinia pestis (agY) for plague diagnosis. The binding of the agY onto the abY-anchored SPHR array resulted in a geometrical change from a ring to a two-humped structure. The reflectance spectra could be used to analyze the AgC attachment and the agY binding onto the abY-anchored SPHR array. The linear range between the wavelength shift and agY concentration from 30 to 270 pg mL

Indexed as

plaguepoly(methacrylic acid) brushreflectance spectrasilver clusters

Identifiers

PMID37112066

DOI10.3390/polym15081919

PMCPMC10143817

OpenAlexW4366286943

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.