Evidence map›Paper›PMID 37111626›Full record

ArticlePharmaceutics2023

Characterization and Molecular Modelling of Non-Antibiotic Nanohybrids for Wound Healing Purposes.

Caterina Valentino, Tomás Martínez Rodríguez, Ana Borrego-Sánchez, Pablo Hernández Benavides, Francisco Arrebola Vargas, José Manuel Paredes, Silvia Rossi, Claro Ignacio Sainz Díaz, Giuseppina Sandri, Pietro Grisoli and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Caterina ValentinoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Tomás Martínez RodríguezDepartment of Pharmacy and Pharmaceutical Technology, Cartuja Campus, University of Granada, 18071 Granada, Spain.
Ana Borrego-SánchezInstituto de Ciencia Molecular, Universitat de València, Carrer del Catedrátic José Beltrán Martinez 2, 46980 Paterna, Spain.ORCID 0000-0002-2589-9716
Pablo Hernández BenavidesDepartment of Pharmacy and Pharmaceutical Technology, Cartuja Campus, University of Granada, 18071 Granada, Spain.
Francisco Arrebola VargasDepartment of Histology, Institute of Neurosciences, Centre for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.ORCID 0000-0002-5030-3339
José Manuel ParedesNanoscopy-UGR Laboratory, Department of Physical Chemistry, Unidad de Excelencia en Quimica Aplicada a Biomedicina y Medioambiente UEQ, University of Granada, Cartuja Campus, 18071 Granada, Spain.ORCID 0000-0002-3252-9174
Silvia RossiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-9511-3857
Claro Ignacio Sainz DíazInstituto Andaluz de Ciencias de la Tierra (CSIC-University of Granada), 18100 Armilla, Spain.
Giuseppina SandriDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-6766-9321
Pietro GrisoliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-2016-0135
María Del Mar Medina PérezDepartment of Pharmacy and Pharmaceutical Technology, Cartuja Campus, University of Granada, 18071 Granada, Spain.
Carola AguzziDepartment of Pharmacy and Pharmaceutical Technology, Cartuja Campus, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-4756-5928
Universidad de Granada · ESUniversity of Pavia · ITParc Científic de la Universitat de València · ES

Funding

Junta de Andalucía P18-RT-3786MCIN/AEI /10.13039/501100011033 PID2020-112737RB-I00
6 · The paper itself

Abstract

The healing process of chronic wounds continues to be a current clinical challenge, worsened by the risk of microbial infections and bacterial resistance to the most frequent antibiotics. In this work, non-antibiotic nanohybrids based on chlorhexidine dihydrochloride and clay minerals have been developed in order to design advanced therapeutic systems aimed to enhance wound healing in chronic lesions. To prepare the nanohybrids, two methodologies have been compared: the intercalation solution procedure and the spray-drying technique, the latter as a one-step process able to reduce preparation times. Nanohybrids were then fully studied by solid state characterization techniques. Computational calculations were also performed to assess the interactions between the drug and the clays at the molecular level. In vitro human fibroblast biocompatibility and antimicrobial activity against

Indexed as

antibiotic resistanceantimicrobial propertiesbentonitebiocompatibilitychlorhexidinechronic woundshalloysitemolecular modellingspray dryingwound healing

Identifiers

PMID37111626
PMCPMC10142211
OpenAlexW4362558032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.