Evidence map›Paper›PMID 37111623›Full record

ArticlePharmaceutics2023

Nanothin Conformal Coating with Poly(N-vinylpyrrolidone) and Tannic Acid (PVPON/TA) Preserves Murine and Human Pancreatic Islets Function.

Kateryna Polishevska, Sandra Kelly, Purushothaman Kuppan, Karen L Seeberger, Saloni Aggarwal, Joy Paramor, Larry D Unsworth, Hubert M Tse, Gregory S Korbutt, Andrew R Pepper

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kateryna PolishevskaAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.
Sandra KellyAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.ORCID 0009-0008-4746-5864
Purushothaman KuppanAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.ORCID 0000-0001-6256-7692
Karen L SeebergerAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.
Saloni AggarwalAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.
Joy ParamorAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.
Larry D UnsworthDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Hubert M TseDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Gregory S KorbuttAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.ORCID 0000-0001-9690-4351
Andrew R PepperAlberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2T9, Canada.ORCID 0000-0002-2227-4446
University of Alberta · CAUniversity of Kansas Medical Center · US

Funding

Juvenile Diabetes Research Foundation 5-CDA- 2020-945-A-N
6 · The paper itself

Abstract

Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulation strategies can reduce the inherent adaptive immune response; however, few are successfully translated into clinical testing. Herein, we evaluated if the conformal coating of islets with poly(N-vinylpyrrolidone) (PVPON) and tannic acid (TA) (PVPON/TA) could preserve murine and human islet function while conferring islet allograft protection. In vitro function was evaluated using static glucose-stimulated insulin secretion, oxygen consumption rates, and islet membrane integrity. In vivo function was evaluated by transplanting human islets into diabetic immunodeficient B6.129S7-Rag

Indexed as

allotransplantationconformal coatingencapsulationhuman isletsislet transplantationtype 1 diabetes

Identifiers

PMID37111623
PMCPMC10143619
OpenAlexW4362560840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.