Evidence map›Paper›PMID 37111590›Full record

ArticlePharmaceutics2023

Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties-From Suspension to In Vitro Studies.

Barbara Freis, Maria De Los Angeles Ramirez, Céline Kiefer, Sébastien Harlepp, Cristian Iacovita, Céline Henoumont, Christine Affolter-Zbaraszczuk, Florent Meyer, Damien Mertz, Anne Boos and 6 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Barbara FreisUMR CNRS-UdS 7504, Institut de Physique et Chimie des Matériaux, CNRS, Université de Strasbourg, 23 Rue du Loess, BP 43, 67034 Strasbourg, France.ORCID 0000-0003-0738-7976
Maria De Los Angeles RamirezUMR CNRS-UdS 7504, Institut de Physique et Chimie des Matériaux, CNRS, Université de Strasbourg, 23 Rue du Loess, BP 43, 67034 Strasbourg, France.
Céline KieferUMR CNRS-UdS 7504, Institut de Physique et Chimie des Matériaux, CNRS, Université de Strasbourg, 23 Rue du Loess, BP 43, 67034 Strasbourg, France.
Sébastien HarleppTumor Biomechanics, INSERM UMR S1109, Institut d'Hématologie et d'Immunologie, 67091 Strasbourg, France.ORCID 0000-0001-8891-7953
Cristian IacovitaDepartment of Pharmaceutical Physics-Biophysics, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 6 Pasteur St., 400349 Cluj-Napoca, Romania.ORCID 0000-0001-5398-1445
Céline HenoumontDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, UMONS, 19 Avenue Maistriau, 7000 Mons, Belgium.ORCID 0000-0002-3280-2441
Christine Affolter-ZbaraszczukInserm U1121, Centre de Recherche en Biomédecine de Strasbourg, 1 Rue Eugène Boeckel, CS 60026, CEDEX, 67084 Strasbourg, France.
Florent MeyerInserm U1121, Centre de Recherche en Biomédecine de Strasbourg, 1 Rue Eugène Boeckel, CS 60026, CEDEX, 67084 Strasbourg, France.ORCID 0000-0002-5275-3421
Damien MertzUMR CNRS-UdS 7504, Institut de Physique et Chimie des Matériaux, CNRS, Université de Strasbourg, 23 Rue du Loess, BP 43, 67034 Strasbourg, France.ORCID 0000-0002-6745-8978
Anne BoosIPHC UMR 7178, CNRS, Université de Strasbourg, 67000 Strasbourg, France.ORCID 0000-0002-9918-3884
Mariana TassoInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata-CONICET, Diagonal 113 y 64, La Plata 1900, Argentina.ORCID 0000-0002-2841-5158
Sonia FurgiueleDepartment of Human Anatomy and Experimental Oncology, Faculty of Medicine, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 8, 7000 Mons, Belgium.
Fabrice JourneDepartment of Human Anatomy and Experimental Oncology, Faculty of Medicine, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 8, 7000 Mons, Belgium.
Sven SaussezDepartment of Human Anatomy and Experimental Oncology, Faculty of Medicine, Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 8, 7000 Mons, Belgium.ORCID 0000-0002-3655-1854
Sylvie Bégin-ColinUMR CNRS-UdS 7504, Institut de Physique et Chimie des Matériaux, CNRS, Université de Strasbourg, 23 Rue du Loess, BP 43, 67034 Strasbourg, France.
Sophie LaurentDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, UMONS, 19 Avenue Maistriau, 7000 Mons, Belgium.ORCID 0000-0002-2589-3250
Centre National de la Recherche Scientifique · FRUniversity of Mons · BEInserm · FRConsejo Nacional de Investigaciones Científicas y Técnicas · ARIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r

Indexed as

iron oxide nanocubes and nanoplatesmagnetic hyperthermiaMRI contrast agentphotothermiatargeting ligand

Identifiers

PMID37111590
PMCPMC10143744
OpenAlexW4361279913

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.