Evidence map›Paper›PMID 37111575›Full record

ArticlePharmaceutics2023

Dried Blood Spot Sampling to Assess Rifampicin Exposure and Treatment Outcomes among Native and Non-Native Tuberculosis Patients in Paraguay: An Exploratory Study.

Samiksha Ghimire, Gladys Molinas, Arturo Battaglia, Nilza Martinez, Luis Gómez Paciello, Sarita Aguirre, Jan-Willem C Alffenaar, Marieke G G Sturkenboom, Cecile Magis-Escurra

Abstract read
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In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samiksha GhimireDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands.ORCID 0000-0002-6028-1460
Gladys MolinasInstituto Nacional de Enfermedades Respiratorias y del Ambiente "Juan Max Boettner", Asuncion 1430, Paraguay.
Arturo BattagliaInstituto Nacional de Enfermedades Respiratorias y del Ambiente "Juan Max Boettner", Asuncion 1430, Paraguay.
Nilza MartinezInstituto Nacional de Enfermedades Respiratorias y del Ambiente "Juan Max Boettner", Asuncion 1430, Paraguay.
Luis Gómez PacielloInstituto Nacional de Enfermedades Respiratorias y del Ambiente "Juan Max Boettner", Asuncion 1430, Paraguay.ORCID 0000-0002-8213-3004
Sarita AguirrePrograma Nacional de Control de la Tuberculosis, Asuncion 1430, Paraguay.
Jan-Willem C AlffenaarSchool of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0001-6703-0288
Marieke G G SturkenboomDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands.ORCID 0000-0002-3420-0591
Cecile Magis-EscurraDepartment of Pulmonary Diseases, Radboud University Medical Center-TB Expert Center Dekkerswald, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-8424-9425

Funding

European Union 823890
6 · The paper itself

Abstract

The aim of this study was to evaluate the difference in drug exposure of rifampicin in native versus non-native Paraguayan populations using dried blood spots (DBS) samples collected utilizing a limited sampling strategy. This was a prospective pharmacokinetic study that enrolled hospitalized tuberculosis (TB) patients from both native and non-native populations receiving oral rifampicin 10 mg/kg once-daily dosing. Steady-state DBS samples were collected at 2, 4, and 6 h after intake of rifampicin. The area under the time concentration curve 0-24 h (AUC

Indexed as

dried blood spotslimited-sampling strategypharmacokineticsrifampicintuberculosis

Identifiers

PMID37111575
PMCPMC10146788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.