Evidence map›Paper›PMID 37111471›Full record

ArticlePathogens (Basel, Switzerland)2023

Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study.

Robert N Lopez, Steven T Leach, Nerissa Bowcock, Elise Coker, Amanda J Shapiro, Andrew S Day, Daniel A Lemberg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Robert N LopezDepartment of Gastroenterology, Sydney Children's Hospital, Sydney 2031, Australia.
Steven T LeachDepartment of Paediatrics, School of Clinical Medicine, University of NSW, Sydney 2052, Australia.
Nerissa BowcockDepartment of Paediatrics, School of Clinical Medicine, University of NSW, Sydney 2052, Australia.
Elise CokerDepartment of Gastroenterology, Sydney Children's Hospital, Sydney 2031, Australia.
Amanda J ShapiroDepartment of Paediatrics, School of Clinical Medicine, University of NSW, Sydney 2052, Australia.
Andrew S DayDepartment of Paediatrics, School of Clinical Medicine, University of NSW, Sydney 2052, Australia.ORCID 0000-0003-2290-7386
Daniel A LembergDepartment of Gastroenterology, Sydney Children's Hospital, Sydney 2031, Australia.
UNSW Sydney · AUSydney Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of gastrointestinal microbiome in health and disease is increasingly appreciated. A significant amount of evidence clearly points to a dysbiosis manifest in inflammatory bowel disease (IBD) when compared to healthy controls. Less understood is the microbiome profile in autoimmune liver disease (AILD). Both adult and paediatric data indicate a distinct microbial signature in patients with IBD and co-existent primary sclerosing cholangitis (PSC), which is unique and different compared to the microbial signature that exists in patients with IBD alone. However, there is limited information on the microbiome make-up of patients with parenchymal liver disease, with or without IBD.

methodsThe present study sought to compare the microbiome of children with IBD, to those with IBD-AILD, those with AILD alone and those of healthy controls.

resultsResults from this work indicate that children with AILD have a microbiome profile that mirrors healthy controls.

conclusionThose with IBD-AILD and IBD have similar microbiome profiles which are distinct from AILD alone and healthy controls. This suggests that the dysbiosis in these groups is primarily due to IBD rather than AILD.

Indexed as

autoimmune liver diseaseinflammatory bowel diseasemicrobiomepaediatricsprimary sclerosing cholangitis

Identifiers

PMID37111471
PMCPMC10145405
OpenAlexW4365453525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.