Evidence map›Paper›PMID 37111420›Full record

ArticlePathogens (Basel, Switzerland)2023

Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated

Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K Dagur, Adovi Akue, Mark KuKuruga, Hira L Nakhasi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Parna BhattacharyaDivision of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research Food and Drug Administration, Silver Spring, MD 20993, USA.
Sreenivas GannavaramDivision of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research Food and Drug Administration, Silver Spring, MD 20993, USA.ORCID 0000-0002-6557-8220
Nevien IsmailDivision of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research Food and Drug Administration, Silver Spring, MD 20993, USA.
Ankit SaxenaImmune Monitoring Shared Resource, Rutgers, Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
Pradeep K DagurFlow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Adovi AkueDivision of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research Food and Drug Administration, Silver Spring, MD 20993, USA.
Mark KuKurugaDivision of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research Food and Drug Administration, Silver Spring, MD 20993, USA.
Hira L NakhasiDivision of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research Food and Drug Administration, Silver Spring, MD 20993, USA.ORCID 0000-0003-4941-1620
Center for Biologics Evaluation and Research · USNational Institutes of Health · USRutgers, The State University of New Jersey · US

Funding

Flow Cytometry Core FacilityZICHL005905 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DAGUR, PRADEEP · 2009 to 2025
$32.3M
intramural funds of the Center for Biologics Evaluation and Research, U.S. Food and Drug Administration (FDA) for HLN. Intramural Funds
6 · The paper itself

Abstract

No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted

Indexed as

costimulatory moleculescytokinesdendritic cellsinnate immunitymyeloid differentiation primary response 88nuclear factor-kappa Bvisceral leishmaniasis

Identifiers

PMID37111420
PMCPMC10143410
OpenAlexW4361268626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.