Evidence map›Paper›PMID 37111339›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

In Vitro and In Vivo Functional Viability, and Biocompatibility Evaluation of Bovine Serum Albumin-Ingrained Microemulsion: A Model Based on Sesame Oil as the Payload for Developing an Efficient Drug Delivery Platform.

Atiaf Rhyaf, Hala Naji, Hassan Al-Karagoly, Salim Albukhaty, Ghassan M Sulaiman, Abdulaziz Arif A Alshammari, Hamdoon A Mohammed, Majid Jabir, Riaz A Khan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Atiaf RhyafDepartment of Pathology, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah 58002, Iraq.
Hala NajiDepartment of Pathology, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah 58002, Iraq.
Hassan Al-KaragolyDepartment of Internal and Preventive Medicine, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah 58002, Iraq.ORCID 0000-0002-2199-9322
Salim AlbukhatyDepartment of Chemistry, College of Science, University of Misan, Maysan 62001, Iraq.ORCID 0000-0001-7885-4215
Ghassan M SulaimanDivision of Biotechnology, Department of Applied Science, University of Technology, Baghdad 10066, Iraq.ORCID 0000-0001-6388-3849
Abdulaziz Arif A AlshammariDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0002-4502-3797
Hamdoon A MohammedDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0003-2896-6790
Majid JabirDivision of Biotechnology, Department of Applied Science, University of Technology, Baghdad 10066, Iraq.ORCID 0000-0003-0759-8298
Riaz A KhanDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0003-0185-0149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combination of bovine serum albumin with microemulsions as constituting ingredient biopolymer has long been regarded an innovative method to address the surface functionalization and stability issues in the targeted payload deliveries, thereupon producing effectively modified microemulsions, which are superior in loading capacity, transitional and shelf-stability, as well as site-directed/site-preferred delivery, has become a favored option. The current study aimed to develop an efficient, suitable and functional microemulsion system encapsulating sesame oil (SO) as a model payload towards developing an efficient delivery platform. UV-VIS, FT-IR, and FE-SEM were used to characterize, and analyze the developed carrier. Physicochemical properties assessments of the microemulsion by dynamic light scattering size distributions, zeta-potential, and electron micrographic analyses were performed. The mechanical properties for rheological behavior were also studied. The HFF-2 cell line and hemolysis assays were conducted to ascertain the cell viability, and in vitro biocompatibility. The in vivo toxicity was determined based on a predicted median lethal dose (LD

Indexed as

biocompatibilitybiological markerbovine serum albumincytotoxicitydrug deliveryfunctional viabilityhepatic functionsLD50liver biomarkersmicroemulsionnanomedicinenanoparticlessesame oiltoxicity

Identifiers

PMID37111339
PMCPMC10141236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.