Evidence map›Paper›PMID 37111333›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Synthesis, In Silico and In Vitro Characterization of Novel

Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-Hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam, Sang-Yoon Lee

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jaekyung ParkGachon Advanced Institute for Health Science and Technology, Graduate School, Gachon University, Incheon 21999, Republic of Korea.
Sobia WasimDepartment of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Republic of Korea.ORCID 0000-0002-6658-8404
Jae Ho JungDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Mi-Hyun KimGachon Institute of Pharmaceutical Science and Department of Pharmacy, College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.ORCID 0000-0002-2718-5637
Byung Chul LeeDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.ORCID 0000-0002-1425-5712
Mohammad Maqusood AlamNeuroscience Research Institute, Gachon University, Incheon 20565, Republic of Korea.ORCID 0000-0002-0842-6992
Sang-Yoon LeeGachon Advanced Institute for Health Science and Technology, Graduate School, Gachon University, Incheon 21999, Republic of Korea.ORCID 0000-0002-6029-8553
Gachon University · KRSeoul National University Bundang Hospital · KR

Funding

Korea Health Industry Development Institute HI14C1135National Research Foundation of Korea 2017R1D1A1B03033429
6 · The paper itself

Abstract

The translocator protein (TSPO) is an interesting biological target for molecular imaging and therapy because the overexpression of TSPO is associated with microglial activation caused by neuronal damage or neuroinflammation, and these activated microglia are involved in various central nervous system (CNS) diseases. The TSPO is a target for neuroprotective treatment, which is used with the aim of reducing microglial cell activation. The novel

Indexed as

central nervous system (CNS)MD simulationmicrogliamolecular dockingneurodegenerative diseaseneuroinflammationpyrazolopyrimidinetranslocator protein (TSPO)

Identifiers

PMID37111333
PMCPMC10142799
OpenAlexW4365146960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.