Evidence map›Paper›PMID 37111303›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Improved Local Anesthesia at Inflamed Tissue Using the Association of Articaine and Copaiba Oil in Avocado Butter Nanostructured Lipid Carriers.

Gustavo Henrique Rodrigues da Silva, Julia Borges Paes Lemes, Gabriela Geronimo, Fabíola Vieira de Carvalho, Talita Cesarim Mendonça, Kauê Franco Malange, Fernando Freitas de Lima, Márcia Cristina Breitkreitz, Carlos Amilcar Parada, Teresa Dalla Costa and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Gustavo Henrique Rodrigues da SilvaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.ORCID 0000-0001-7377-8532
Julia Borges Paes LemesDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.
Gabriela GeronimoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.
Fabíola Vieira de CarvalhoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.ORCID 0000-0002-4450-0563
Talita Cesarim MendonçaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.
Kauê Franco MalangeDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.
Fernando Freitas de LimaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.
Márcia Cristina BreitkreitzDepartment of Analytical Chemistry, Institute of Chemistry, University of Campinas-UNICAMP, Campinas 13083-970, SP, Brazil.
Carlos Amilcar ParadaDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.
Teresa Dalla CostaDepartment of Production and Control of Medicines, Faculty of Pharmacy, Federal University of Rio Grande do Sul-UFRGS, Porto Alegre 90610-000, RS, Brazil.ORCID 0000-0001-9227-2991
Eneida de PaulaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, SP, Brazil.ORCID 0000-0003-4504-5723
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 19/2551-0002278-6Institutos Nacionais de Ciência e Tecnologia INCT BioanalíticaSão Paulo Research Foundation 17/15174-5; 19/17784-0
6 · The paper itself

Abstract

Unsuccessful anesthesia often occurs under an inflammatory tissue environment, making dentistry treatment extremely painful and challenging. Articaine (ATC) is a local anesthetic used at high (4%) concentrations. Since nanopharmaceutical formulations may improve the pharmacokinetics and pharmacodynamics of drugs, we encapsulated ATC in nanostructured lipid carriers (NLCs) aiming to increase the anesthetic effect on the inflamed tissue. Moreover, the lipid nanoparticles were prepared with natural lipids (copaiba (

Indexed as

articainedrug delivery systemsinflammationlocal anestheticsnanostructured lipid carriers

Identifiers

PMID37111303
PMCPMC10143371
OpenAlexW4362665178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.