Glycoconjugates of Mucochloric Acid-Synthesis and Biological Activity.

Katarzyna Żurawska, Daria Burdalska, Magdalena Skonieczna, Anna Byczek-Wyrostek, Anahit Dawicka, Anna Kasprzycka, Krzysztof Walczak

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

3,4-Dihalo-5-hydroxy-2(5Molecules (Basel, Switzerland) · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katarzyna ŻurawskaDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego Street 4, 44-100 Gliwice, Poland.ORCID 0000-0003-3023-6260

Daria BurdalskaDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego Street 4, 44-100 Gliwice, Poland.

Magdalena SkoniecznaBiotechnology Centre, The Silesian University of Technology, Krzywoustego Street 8, 44-100 Gliwice, Poland.ORCID 0000-0002-6263-9585

Anna Byczek-WyrostekBiotechnology Centre, The Silesian University of Technology, Krzywoustego Street 8, 44-100 Gliwice, Poland.

Anahit DawickaBiotechnology Centre, The Silesian University of Technology, Krzywoustego Street 8, 44-100 Gliwice, Poland.

Anna KasprzyckaDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego Street 4, 44-100 Gliwice, Poland.ORCID 0000-0002-9362-719X

Krzysztof WalczakDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego Street 4, 44-100 Gliwice, Poland.ORCID 0000-0001-8511-2009

Funding

National Science Center 2016/21/B/NZ7/01766Silesian University of Technology 02/040/BK_23/1035

6 · The paper itself

Abstract

The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and medicinal chemistry. These components can be useful tools to tailoring the bioavailability of target molecules. Herein we present the study on the impact of the sugar substituent structure and triisopropylsilyl group presence on the anticancer activity of mucochloric acid (MCA) derivatives containing the furan-2(5

Indexed as

2H-pyrrol-2-one3,4-dichloro-furan-2(5H)-oneanticancer activityclick chemistryglycoconjugate

Identifiers

PMID37111282

DOI10.3390/ph16040525

PMCPMC10143444

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.