Evidence map›Paper›PMID 37111273›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones.

M Shaheer Malik, Shaikh Faazil, Meshari A Alsharif, Qazi Mohammad Sajid Jamal, Jabir H Al-Fahemi, Amrita Banerjee, Arpita Chattopadhyay, Samir Kumar Pal, Ahmed Kamal, Saleh A Ahmed

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M Shaheer MalikDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-5916-9041
Shaikh FaazilDepartment of Chemistry, Poona College of Arts, Science and Commerce, Pune 411001, India.
Meshari A AlsharifDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Qazi Mohammad Sajid JamalDepartment of Health Informatics, College of Public Health and Health Informatics, Qassim University, Al Bukayriyah 52741, Saudi Arabia.ORCID 0000-0001-5525-708X
Jabir H Al-FahemiDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Amrita BanerjeeDepartment of Physics, Jadavpur University, 188, Raja S.C. Mallick Rd., Kolkata 700032, India.
Arpita ChattopadhyayDepartment of Basic Science and Humanities, Techno International New Town, Block-DG 1/1, Action Area 1, New Town, Rajarhat, Kolkata 700156, India.
Samir Kumar PalDepartment of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India.
Ahmed KamalDepartment of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Saleh A AhmedDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-2364-0380

Funding

Umm al-Qura University 22UQU4420116DSR01
6 · The paper itself

Abstract

The mounting evidence of bacterial resistance against commonly prescribed antibiotics warrants the development of new antibacterial drugs on an urgent basis. Linezolid, an oxazolidinone antibiotic, is a lead molecule in designing new oxazolidinones as antibacterial agents. In this study, we report the antibacterial potential of the novel oxazolidinone-sulphonamide/amide conjugates that were recently reported by our research group. The antibacterial assays showed that, from the series, oxazolidinones

Indexed as

ADME propertiesantibacteriallinezolidmolecular dynamicsmolecular modelingoxazolidinone

Identifiers

PMID37111273
PMCPMC10143092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.