Evidence map›Paper›PMID 37111266›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Hylin-a1: A Host Defense Peptide with Antibacterial Potential against

Annalisa Chianese, Carla Zannella, Francesco Foglia, Bianca Maria Nastri, Alessandra Monti, Nunzianna Doti, Gianluigi Franci, Anna De Filippis, Massimiliano Galdiero

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Review
  7. Oreoch-1: A Peptide fromPathogens (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Annalisa ChianeseDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1648-4519
Carla ZannellaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-7991-8700
Francesco FogliaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Bianca Maria NastriDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Alessandra MontiInstitute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80131 Naples, Italy.
Nunzianna DotiInstitute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80131 Naples, Italy.
Gianluigi FranciDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-3321-4331
Anna De FilippisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-0395-7962
Massimiliano GaldieroDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1576-6290
University of Campania "Luigi Vanvitelli" · ITInstitute of Biostructure and Bioimaging · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the resistance of pathogenic microorganisms to common antimicrobial agents has raised to a severe public health problem. The moderate and wise use of antimicrobials and the prevention of infections are the most effective strategies for decreasing the spread and development of resistance. Therefore, the World Health Organization (WHO) has intensified the search for new drugs to fight emerging pathogens. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), play a crucial role in innate immunity, representing one of the first line of defense against microbial attacks. In this study, we evaluated the antibacterial activity of the AMP named Hylin-a1 (derived from the skin of the frog

Indexed as

AMPAMPsantibacterialinflammationmulti-drug resistancepeptidesStaphylococcus aureus

Identifiers

PMID37111266
PMCPMC10145825
OpenAlexW4361274805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.