Evidence map›Paper›PMID 37111252›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Binding Parameters of [

Avinash H Bansode, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Ivan Krizan, Mack Miller, Suzanne Craft, Akiva Mintz, Kiran Kumar Solingapuram Sai

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Imaging Microtubule Dynamics In Vivo in Human Brain: Optimal Quantification Based on a Test-Retest Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Article
  5. Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Development and Optimization ofACS pharmacology & translational science · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Avinash H BansodeDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.ORCID 0000-0002-4802-578X
Bhuvanachandra BhoopalDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Krishna Kumar GollapelliDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Naresh DamukaDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Ivan KrizanDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Mack MillerDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Suzanne CraftDepartment of Gerontology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Akiva MintzDepartment of Radiology, Columbia Medical Center, New York, NY 10032, USA.
Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.ORCID 0000-0002-6442-5169
Wake Forest University · USColumbia University Irving Medical Center · US

Funding

Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's diseaseR01AG065839 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLINGAPURAM SAI, KIRAN · 2020 to 2024
$2.5M
NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG065839NIA NIH HHS R01AG065839
6 · The paper itself

Abstract

Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer's disease (AD), Parkinson's disease and other neurological disorders. Increasing scientific evidence indicates that MT-stabilizing agents protect against the deleterious effects of neurodegeneration in treating AD. To quantify these protective benefits, we developed the first brain-penetrant PET radiopharmaceutical, [

Indexed as

metabolismmicrotubulesPET imagingradiochemistrystabilitytranslational molecular imaging

Identifiers

PMID37111252
PMCPMC10140836
OpenAlexW4361005821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.