Evidence map›Paper›PMID 37111235›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Analytical Quality by Design: Achieving Robustness of an LC-CAD Method for the Analysis of Non-Volatile Fatty Acids.

Rasmus Walther, Jovana Krmar, Adrian Leistner, Bojana Svrkota, Biljana Otašević, Andjelija Malenović, Ulrike Holzgrabe, Ana Protić

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rasmus WaltherInstitute for Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0001-6174-6760
Jovana KrmarDepartment of Drug Analysis, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11 221 Belgrade, Serbia.
Adrian LeistnerInstitute for Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Bojana SvrkotaDepartment of Drug Analysis, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11 221 Belgrade, Serbia.
Biljana OtaševićDepartment of Drug Analysis, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11 221 Belgrade, Serbia.ORCID 0000-0002-4747-927X
Andjelija MalenovićDepartment of Drug Analysis, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11 221 Belgrade, Serbia.
Ulrike HolzgrabeInstitute for Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-0364-7278
Ana ProtićDepartment of Drug Analysis, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11 221 Belgrade, Serbia.

Funding

Ministry of Education and Science of Germany and the Ministry of Education, Science and Technological Development, Republic of Serbia Grant Agreement with University of Belgrade-Faculty of Pharmacy No: 451-03-47/2023-01/200161
6 · The paper itself

Abstract

An alternative to the time-consuming and error-prone pharmacopoeial gas chromatography method for the analysis of fatty acids (FAs) is urgently needed. The objective was therefore to propose a robust liquid chromatography method with charged aerosol detection for the analysis of polysorbate 80 (PS80) and magnesium stearate. FAs with different numbers of carbon atoms in the chain necessitated the use of a gradient method with a Hypersil Gold C

Indexed as

Analytical Quality by Designcharged aerosol detectorfatty acidsmagnesium stearatepolysorbate 80

Identifiers

PMID37111235
PMCPMC10145151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.