Evidence map›Paper›PMID 37111097›Full record

SynthesisNutrients2023

Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium.

Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S Rabkin, Linda M Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni and 27 more

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The global gastric cancer consortium: an update from the Stomach cancer Pooling (StoP) project.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2024
    Article
  4. Review
  5. Risk Prediction Models for Gastric Cancer: A Scoping Review.Journal of multidisciplinary healthcare · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 19 institutions in 8 countries.

Giulia CollatuzzoDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-2309-7365
Eva NegriDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Claudio PelucchiDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
Rossella BonziDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-2155-6126
Federica TuratiDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-5841-5773
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, 50139 Florence, Italy.ORCID 0000-0002-5558-2437
Monica FerraroniDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0002-4542-4996
Lizbeth López-CarrilloMexico National Institute of Public Health, Cuernavaca 62100, Mexico.ORCID 0000-0002-3245-8337
Nuno LunetEPIUnit-Instituto de Saúde Pública da Universidade do Porto, 4050-600 Porto, Portugal.ORCID 0000-0003-1870-1430
Samantha MoraisEPIUnit-Instituto de Saúde Pública da Universidade do Porto, 4050-600 Porto, Portugal.ORCID 0000-0001-5808-0179
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.ORCID 0000-0002-3834-1535
Dominick ParisiInformation management Services, Inc., Silver Spring, MD 20904, USA.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, 115478 Moscow, Russia.ORCID 0000-0002-2824-3704
Dmitry MaximovitchDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, 115478 Moscow, Russia.
Trinidad Dierssen-SotosConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.ORCID 0000-0002-6127-0077
José Juan Jiménez-MoleónConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.ORCID 0000-0001-7917-6145
Jesus VioqueConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.ORCID 0000-0002-2284-148X
Manoli Garcia de la HeraConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.ORCID 0000-0001-5742-2704
Maria Paula CuradoCentro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo 01508-010, Brazil.
Emmanuel Dias-NetoCentro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo 01508-010, Brazil.ORCID 0000-0001-5670-8559
Raúl Ulises Hernández-RamírezDepartment of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA.
Malaquias López-CervantesFacultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Coyoacán 04510, Mexico.
Mary H WardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.ORCID 0000-0001-7584-8856
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan.ORCID 0000-0003-4105-2774
Akihisa HidakaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan.
Areti LagiouDepartment of Public and Community Health, School of Public Health, University of West Attica, 11521 Athens, Greece.ORCID 0000-0002-6687-358X
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Jonsson Comprehensive Cancer Center, Los Angeles, CA 10833, USA.ORCID 0000-0002-4669-3995
Antonia TrichopoulouHellenic Health Foundation, 11527 Athens, Greece.
Anna KarakatsaniHellenic Health Foundation, 11527 Athens, Greece.ORCID 0000-0002-3275-2026
Maria Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.ORCID 0000-0002-1065-2198
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-1441-897X
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-3811-2791
National Cancer Institute · USUniversity of Milan · ITAC Camargo Hospital · BRUniversidade do Porto · PTUniversitat de Miguel Hernández d'Elx · ESUniversity of Bologna · ITHarvard University · USHellenic Health Foundation · GRInformation Management Services · USInstituto Nacional de Salud Pública · MXNational and Kapodistrian University of Athens · GRNational Institute of Infectious Diseases · JPStony Brook University · USUCLA Health · USUniversidad de Cantabria · ESUniversidad de Granada · ESUniversidad Nacional Autónoma de México · MXUniversity of West Attica · GRYale University · US

Funding

Italian Association for Cancer Research 21378
6 · The paper itself

Abstract

backgroundYoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC).

methodsWe pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted.

resultsThe analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women.

conclusionsWe found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.

Indexed as

AdenocarcinomaHelicobacter InfectionsStomach NeoplasmsCase-Control StudiesFemaleHumansLogistic ModelsMaleRisk Factorsdietgastric cancernutritionyoghurt

Identifiers

PMID37111097
PMCPMC10147010
OpenAlexW4365515434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.