Evidence map›Paper›PMID 37110764›Full record

ArticleMolecules (Basel, Switzerland)2023

Tuning the Biological Activity of PI3K

Wojciech Pietruś, Mariola Stypik, Marcin Zagozda, Martyna Banach, Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Arkadiusz Leniak, Rafał Kurczab, Zbigniew Ochal, Krzysztof Dubiel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Wojciech PietruśDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.ORCID 0000-0002-8563-7929
Mariola StypikCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.ORCID 0000-0002-4200-868X
Marcin ZagozdaCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.
Martyna BanachCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.
Lidia Gurba-BryśkiewiczCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.ORCID 0000-0002-7807-6641
Wioleta MaruszakCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.ORCID 0000-0002-4922-4465
Arkadiusz LeniakCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.ORCID 0000-0002-4462-4603
Rafał KurczabDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.ORCID 0000-0002-9555-3905
Zbigniew OchalFaculty of Chemistry, Warsaw University of Technology, ul. Nowakowskiego 3, 00-664 Warsaw, Poland.ORCID 0000-0002-2723-3782
Krzysztof DubielCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.
Maciej WieczorekCelon Pharma S.A., ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland.
Celon Pharma (Poland) · PLWarsaw University of Technology · PLMaj Institute of Pharmacology · PL

Funding

National Science Centre, Poland 2019/35/N/NZ7/04312
6 · The paper itself

Abstract

As a member of the class I PI3K family, phosphoinositide 3-kinase

Indexed as

FluorinePhosphatidylinositol 3-KinasesMolecular Docking SimulationMolecular Dynamics SimulationWorkflowFluorinePhosphatidylinositol 3-KinasesasthmaCPL302415fluorineinduced-fit dockingMDMM-GBSAmolecular dockingPI3KδQPLD

Identifiers

PMID37110764
PMCPMC10145010
OpenAlexW4366188511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.