Evidence map›Paper›PMID 37110737›Full record

ArticleMolecules (Basel, Switzerland)2023

Determination of Some Isoquinoline Alkaloids in Extracts Obtained from Selected Plants of the Ranunculaceae, Papaveraceae and Fumarioideae Families by Liquid Chromatography and In Vitro and In Vivo Investigations of Their Cytotoxic Activity.

Justyna Misiurek, Tomasz Plech, Barbara Kaproń, Anna Makuch-Kocka, Małgorzata Szultka-Młyńska, Bogusław Buszewski, Anna Petruczynik

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Plants (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Justyna MisiurekDepartment of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0002-0791-4222
Tomasz PlechDepartment of Pharmacology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.ORCID 0000-0002-8162-8435
Barbara KaprońDepartment of Clinical Genetics, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.ORCID 0000-0002-7520-3238
Anna Makuch-KockaDepartment of Pharmacology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.ORCID 0000-0001-8082-535X
Małgorzata Szultka-MłyńskaDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun, Poland.ORCID 0000-0002-4499-0128
Bogusław BuszewskiDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun, Poland.ORCID 0000-0002-5482-7500
Anna PetruczynikDepartment of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-3294-3217
Medical University of Lublin · PLNicolaus Copernicus University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alkaloids are heterocyclic bases with widespread occurrence in nature. Plants are rich and easily accessible sources of them. Most isoquinoline alkaloids have cytotoxic activity for different types of cancer, including malignant melanoma, the most aggressive type of skin cancer. The morbidity of melanoma has increased worldwide every year. For that reason, developing new candidates for anti-melanoma drugs is highly needed. The aim of this study was to investigate the alkaloid compositions of plant extracts obtained from

Indexed as

AlkaloidsAntineoplastic AgentsMelanomaPapaveraceaeRanunculaceaeSkin NeoplasmsAnimalsChromatography, High Pressure LiquidChromatography, LiquidCutaneous Malignant MelanomaHumansIsoquinolinesPlant ExtractsTandem Mass SpectrometryZebrafishAlkaloidsAntineoplastic AgentsIsoquinolinesPlant Extractscytotoxic activitydanio rerio larvae xenograft modelHPLC-DADisoquinoline alkaloidsLC-MS/MSplant extracts

Identifiers

PMID37110737
PMCPMC10143472
OpenAlexW4366122266

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.