Evidence map›Paper›PMID 37110709›Full record

ReviewMolecules (Basel, Switzerland)2023

Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer.

Mohammad Imran, Areeba Insaf, Nazeer Hasan, Vrushabh V Sugandhi, Deumaya Shrestha, Keshav Raj Paudel, Saurav Kumar Jha, Philip M Hansbro, Kamal Dua, Hari Prasad Devkota and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Diterpenoid fromInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Oxidative Stress and Age-Related Tumors.Antioxidants (Basel, Switzerland) · 2024
    Review
  9. Review
  10. Sirtuins as Players in the Signal Transduction ofInternational journal of molecular sciences · 2024
    Review
  11. Methanol extract ofJournal of animal science and technology · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Mohammad ImranTherapeutics Research Group, Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0002-3461-0152
Areeba InsafDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Nazeer HasanDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.ORCID 0000-0002-0785-1735
Vrushabh V SugandhiDepartment of Pharmaceutics, Y.B. Chavan College of Pharmacy, Aurangabad 431001, India.ORCID 0000-0001-7072-5910
Deumaya ShresthaDepartment of Bioscience, Mokp o National University, Muna 58554, Republic of Korea.ORCID 0009-0001-1456-8786
Keshav Raj PaudelCentre of Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0002-3591-2080
Saurav Kumar JhaDepartment of Biomedicine, Health & Life Convergence Sciences, Mokpo National University, Muna 58554, Republic of Korea.ORCID 0000-0002-9207-2997
Philip M HansbroCentre of Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0002-4741-3035
Kamal DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0002-7507-1159
Hari Prasad DevkotaGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.ORCID 0000-0002-0509-1621
Yousuf MohammedTherapeutics Research Group, Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0002-7825-7557
University of Technology Sydney · AUJamia Hamdard · INMokpo National University · KRThe University of Queensland · AUHindu College of Pharmacy · INPokhara University · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-derived compounds, specifically antioxidants, have played an important role in scavenging the free radicals present under diseased conditions. The persistent generation of free radicals in the body leads to inflammation and can result in even more severe diseases such as cancer. Notably, the antioxidant potential of various plant-derived compounds prevents and deregulates the formation of radicals by initiating their decomposition. There is a vast literature demonstrating antioxidant compounds' anti-inflammatory, anti-diabetic, and anti-cancer potential. This review describes the molecular mechanism of various flavonoids, such as quercetin, kaempferol, naringenin, epicatechin, and epicatechin gallate, against different cancers. Additionally, the pharmaceutical application of these flavonoids against different cancers using nanotechnologies such as polymeric, lipid-based nanoparticles (solid-lipid and liquid-lipid), liposomes, and metallic nanocarriers is addressed. Finally, combination therapies in which these flavonoids are employed along with other anti-cancer agents are described, indicating the effective therapies for the management of various malignancies.

Indexed as

AntioxidantsNeoplasmsFlavonoidsHumansLipidsPhytochemicalsAntioxidantsFlavonoidsLipidsPhytochemicalsanticancerantioxidantcombination therapyflavonoidsnanotechnology

Identifiers

PMID37110709
PMCPMC10142939
OpenAlexW4365509921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.