Evidence map›Paper›PMID 37110318›Full record

ReviewMicroorganisms2023

Idiopathic Pulmonary Fibrosis and Post-COVID-19 Lung Fibrosis: Links and Risks.

Filippo Patrucco, Paolo Solidoro, Francesco Gavelli, Daria Apostolo, Mattia Bellan

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  6. Integrating mechanical cues inFrontiers in immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Filippo PatruccoRespiratory Diseases Unit, Medical Department, AOU Maggiore della Carità Hospital, 28100 Novara, Italy.ORCID 0000-0002-4794-8734
Paolo SolidoroMedical Sciences Department, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-3972-2871
Francesco GavelliTranslational Medicine Department, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0002-0581-245X
Daria ApostoloTranslational Medicine Department, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0002-2416-7468
Mattia BellanTranslational Medicine Department, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0003-1488-8736
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · IT

Funding

Fondazione Cariplo 2021-1541
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is considered the paradigmatic example of chronic progressive fibrosing disease; IPF does not result from a primary immunopathogenic mechanism, but immune cells play a complex role in orchestrating the fibrosing response. These cells are activated by pathogen-associated or danger-associated molecular patterns generating pro-fibrotic pathways or downregulating anti-fibrotic agents. Post-COVID pulmonary fibrosis (PCPF) is an emerging clinical entity, following SARS-CoV-2 infection; it shares many clinical, pathological, and immune features with IPF. Similarities between IPF and PCPF can be found in intra- and extracellular physiopathological pro-fibrotic processes, genetic signatures, as well as in the response to antifibrotic treatments. Moreover, SARS-CoV-2 infection can be a cause of acute exacerbation of IPF (AE-IPF), which can negatively impact on IPF patients' prognosis. In this narrative review, we explore the pathophysiological aspects of IPF, with particular attention given to the intracellular signaling involved in the generation of fibrosis in IPF and during the SARS-CoV-2 infection, and the similarities between IPF and PCPF. Finally, we focus on COVID-19 and IPF in clinical practice.

Indexed as

COVID-19idiopathic pulmonary fibrosispost-COVID-19 pulmonary fibrosispulmonary fibrosisSARS-CoV-2

Identifiers

PMID37110318
PMCPMC10146995
OpenAlexW4361268063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.