Evidence map›Paper›PMID 37109514›Full record

ArticleLife (Basel, Switzerland)2023

Comparison of Activity and Safety of DSPAα1 and Its N-Glycosylation Mutants.

Huakang Peng, Nan Wang, Mengqi Wang, Caifeng Yang, Wenfang Guo, Gangqiang Li, Sumei Huang, Di Wei, Dehu Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Recombinant Expression and Activity Analysis of aCurrent issues in molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Huakang PengBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.ORCID 0000-0003-3991-9375
Nan WangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Mengqi WangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Caifeng YangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Wenfang GuoBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Gangqiang LiBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Sumei HuangBiotechnology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China.
Di WeiBiotechnology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China.
Dehu LiuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Chinese Academy of Agricultural Sciences · CNGuangxi Academy of Agricultural Science · CN

Funding

Foundation of Hainan Yazhou Bay Seed Lab B21HJ0212National Natural Science Foundation of China 31901661
6 · The paper itself

Abstract

DSPAα1 is a potent rude thrombolytic protein with high medicative value. DSPAα1 has two natural N-glycan sites (N153Q-S154-S155, N398Q-K399-T400) that may lead to immune responses when administered in vivo. We aimed to study the effect of its N-glycosylation sites on DSPAα1 in vitro and in vivo by mutating these N-glycosylation sites. In this experiment, four single mutants and one double mutant were predicted and expressed in

Indexed as

drug safetyDSPAα1fibrin selectivityN-glycosylation sitesplasminogen activatorrat

Identifiers

PMID37109514
PMCPMC10145227
OpenAlexW4365142319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.