Evidence map›Paper›PMID 37109447›Full record

ArticleLife (Basel, Switzerland)2023

Examining the Role of Hypothalamus-Derived Neuromedin-U (NMU) in Bone Remodeling of Rats.

Gabriella Born-Evers, Ashley L Orr, Elizabeth Q Hulsey, Maria E Squire, Julia M Hum, Lilian Plotkin, Catherine Sampson, Jonathan Hommel, Jonathan W Lowery

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriella Born-EversDivision of Biomedical Science, College of Osteopathic Medicine, Marian University, 3200 Cold Spring Rd, Indianapolis, IN 46222, USA.
Ashley L OrrDivision of Biomedical Science, College of Osteopathic Medicine, Marian University, 3200 Cold Spring Rd, Indianapolis, IN 46222, USA.
Elizabeth Q HulseyDivision of Biomedical Science, College of Osteopathic Medicine, Marian University, 3200 Cold Spring Rd, Indianapolis, IN 46222, USA.
Maria E SquireDepartment of Biology, The University of Scranton, Scranton, PA 18503, USA.
Julia M HumDivision of Biomedical Science, College of Osteopathic Medicine, Marian University, 3200 Cold Spring Rd, Indianapolis, IN 46222, USA.ORCID 0000-0003-4703-7428
Lilian PlotkinDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46222, USA.ORCID 0000-0002-9537-4544
Catherine SampsonDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jonathan HommelDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8305-3746
Jonathan W LoweryDivision of Biomedical Science, College of Osteopathic Medicine, Marian University, 3200 Cold Spring Rd, Indianapolis, IN 46222, USA.ORCID 0000-0002-9942-2945

Funding

Novel Addiction Neurocircuits in Cocaine TakingR01DA053472 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kathryn A. Cunningham, Jonathan Dean Hommel · 2022 to 2026
$2.4M
Integration of Hypothalamic and Limbic Pathways to Regulate Motivation for FoodR01DK106229 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HOMMEL, JONATHAN DEAN · 2016 to 2020
$1.8M
NIDA NIH HHS R01 DA053472NIDDK NIH HHS R01 DK106229NIH HHS R01DK106229, R01DA053472
6 · The paper itself

Abstract

Global loss of the neuropeptide Neuromedin-U (NMU) is associated with increased bone formation and high bone mass in male and female mice by twelve weeks of age, suggesting that NMU suppresses osteoblast differentiation and/or activity in vivo. NMU is highly expressed in numerous anatomical locations including the skeleton and the hypothalamus. This raises the possibility that NMU exerts indirect effects on bone remodeling from an extra-skeletal location such as the brain. Thus, in the present study we used microinjection to deliver viruses carrying short-hairpin RNA designed to knockdown

Indexed as

boneNeuromedin UNMUosteoblast

Identifiers

PMID37109447
PMCPMC10144869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.