Anti-Inflammatory Properties of Plants from Serbian Traditional Medicine.

Inflammation is a natural protective response of the human body to a variety of hostile agents and noxious stimuli. Standard anti-inflammatory therapy includes drugs whose usage is associated with a number of side effects. Since ancient times, natural compounds have been used for the treatment of inflammation. Traditionally, the use of medicinal plants is considered safe, inexpensive, and widely acceptable. In Serbia, traditional medicine, based on the strong belief in the power of medicinal herbs, is the widespread form of treatment. This is supported by the fact that Serbia is classified as one of 158 world centers of biodiversity, which confirms that this country is a treasure of medicinal herbs. Some of the most used herbs for the treatment of inflammations of various causes in Serbian tradition are yarrow, common agrimony, couch grass, onion, garlic, marshmallow, common birch, calendula, liquorice, walnut, St. John's wort, chamomile, peppermint, white willow, sage, and many others. The biological activity and anti-inflammatory effect of selected plants are attributed to different groups of secondary biomolecules such as flavonoids, phenolic acids, sterols, terpenoids, sesquiterpenes, and tannins. This paper provides an overview of plants with traditional anti-inflammatory use in Serbia with reference to available studies that examined this effect. Plants used in traditional medicine could be a powerful source for the development of new remedies. Therefore intensive research on the bioactive potential of medicinal plants in each region should be the focus of scientists around the world.