ReviewJournal of clinical medicine2023
Review of Osteoradionecrosis of the Jaw: Radiotherapy Modality, Technique, and Dose as Risk Factors.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Head and neck squamous cell carcinoma: current and emerging therapeutic strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Causal machine learning for extracting insights from observational radiotherapy data.NPJ digital medicine · 2026Article
- Dental Implants After Head and Neck Radiotherapy: From Chronological Waiting Rules to Implant-Bed-Specific Risk Stratification.Healthcare (Basel, Switzerland) · 2026Review
- Protocol for standardized minimally invasive mouse models of bisphosphonate-related and radiation-induced jaw osteonecrosis.bioRxiv : the preprint server for biology · 2026Article
- Prediction of high-dose regions in the jaw as a basis for decision-making in dental rehabilitation prior to radiotherapy in the head and neck area.Clinical and translational radiation oncology · 2026Article
- Mitophagy activation for jawbone radiation injury therapy via angiogenesis/osteogenesis-active nanozymes.Science China. Life sciences · 2026Article
- Osteoradionecrosis of the chest wall in a patient with invasive ductal carcinoma of the breast: a case report.International journal of surgery case reports · 2026Article
- Article
- Hydrogels for Healing Radiation-Injured Tissues and Organs.Gels (Basel, Switzerland) · 2026Review
- Comment on "Surgical management outcomes of osteoradionecrosis of the temporal bone: two-centres experience".European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Machine Learning Models for Individualized Osteoradionecrosis Risk Prediction in Head and Neck Cancer.Journal of medical systems · 2026Article
- The outcome of digital technology in microvascular free flap reconstruction for ORNJ: a retrospective study.Frontiers in bioengineering and biotechnology · 2026Article
- A Case Series on the Combined Use of Zinc L-Carnosine and Nd:YAG Photobiomodulation for Radiation-Induced Oral Mucositis: Pain Reduction and Lesion Improvement.Case reports in dentistry · 2026Article
- Use of Superficial Temporal Vessels in Reconstructive Oral and Maxillofacial Surgery With Vascularized Free Flaps Among "Frozen Neck" Patients.Laryngoscope investigative otolaryngology · 2025Article
- Incidence of osteoradionecrosis after dental extractions in head and neck cancer patients: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Assessing oral and dental health-related quality of life in head and neck cancer patients at 1, 5, and 10 years: a comparison of the EORTC QLQ43, FACT H&N, and the Orthognathic-QLQ questionnaires.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Comments on: Carcinoma buccal mucosa treated with definitive hypofractionated accelerated radiotherapy: a retrospective analysis of treatment outcomes.Singapore medical journal · 2025Article
- Full-Mouth Digital Dental Rehabilitation Under General Anesthesia in a Post-Treatment Intraoral Squamous Cell Carcinoma Patient: A Case Report.Healthcare (Basel, Switzerland) · 2025Article
- Development of a Preclinical Double Model of Mandibular Irradiated Bone and Osteoradionecrosis in New Zealand Rabbits.Head & neck · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) is the cornerstone of organ-sparing or adjuvant therapy for nearly all head and neck cancers. Unfortunately, aggressive RT or CCRT can result in severe late toxicities, such as osteoradionecrosis of the jaws (ORNJ). The incidence of ORNJ is currently less than 5-6% due to advances in dental preventive care programs, RT planning systems, and RT techniques. Although numerous patient-, tumor-, and treatment-related factors may influence the incidence rates of ORNJ, RT modality (equipment), technique, and dose-volume-related factors are three of the most influential factors. This is mainly because different RT equipment and techniques have different levels of success at delivering the prescribed dose to the focal volume of the treatment while keeping the "organ at risk" safe. ORNJ risk is ultimately determined by mandibular dose, despite the RT technique and method being known predictors. Regardless of the photon delivery method, the radiobiological effects will be identical if the total dose, dose per fraction, and dose distribution within the tissue remain constant. Therefore, contemporary RT procedures mitigate this risk by reducing mandibular dosages rather than altering the ionizing radiation behavior in irradiated tissues. In light of the paucity of studies that have examined the impact of RT modality, technique, and dose-volume-related parameters, as well as their radiobiological bases, the present review aims to provide a comprehensive overview of the published literature on these specific issues to establish a common language among related disciplines and provide a more reliable comparison of research results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.