Evidence map›Paper›PMID 37109179›Full record

ArticleJournal of clinical medicine2023

Auditory Steady-State Response and Hearing Impairment in Survivors of Childhood Bacterial Meningitis in Luanda, Angola.

Mariia Karppinen, Emilie Rugemalira, Okko Savonius, Manuel Leite Cruzeiro, Antti Aarnisalo, Topi Jutila, Tuula Pelkonen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01540838 (Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01540838 phase4completednot on this map

Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola.

TypeinterventionalSponsorUniversity of HelsinkiRan2012 to 2017Enrolled375ConditionsBacterial MeningitisArmsInfusion with paracetamol, Bolus without paracetamol
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mariia KarppinenDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki University Hospital, 00290 HUS Helsinki, Finland.
Emilie RugemaliraChildren's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, 00290 HUS Helsinki, Finland.
Okko SavoniusChildren's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, 00290 HUS Helsinki, Finland.
Manuel Leite CruzeiroDavid Bernardino Children's Hospital, Rua Amilcar Cabral, Maianga, Luanda, Angola.
Antti AarnisaloDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki University Hospital, 00290 HUS Helsinki, Finland.
Topi JutilaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, Helsinki University Hospital, 00290 HUS Helsinki, Finland.
Tuula PelkonenChildren's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, 00290 HUS Helsinki, Finland.ORCID 0000-0002-7688-9059
University of Helsinki · FIClínica Sagrada Esperança · AO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survivors of childhood bacterial meningitis (BM) often develop hearing impairment (HI). In low- and middle-income countries (LMICs), BM continues to be a significant cause of hearing disability. We assessed hearing among BM survivors using auditory steady-state responses (ASSR), providing frequency-specific estimated audiograms, and examined whether ASSR would provide a greater understanding of BM-induced HI. Survivors from two prospective BM trials (ISRCTN62824827; NCT01540838) from Luanda Children's Hospital were examined in a follow-up visit with a median duration of 26 months after BM. The hearing of 50 BM survivors and 19 control children was evaluated using ASSR and auditory brainstem response (ABR) after interview and neurological and otorhinolaryngological examinations. The median age of survivors was 80 (IQR 86) months. We diagnosed HI (better ear hearing ≥ 26 dB) in 9/50 (18%) children. Five of the fifty survivors (10%) and 14/100 ears (14%) had profound HI (>80 dB). Severe-to-profound HI affected all frequencies steadily, affecting only the ears of BM survivors (18/100 vs. 0/38,

Indexed as

bacterial meningitischilddeafnesslow- and middle-income countryobjective audiometrysensorineural hearing lossunilateral hearing loss

Identifiers

PMID37109179
PMCPMC10143662
OpenAlexW4365453793

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.